Assessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailability

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dc.contributor.authorFučík, Jancs
dc.contributor.authorJašek, Vojtěchcs
dc.contributor.authorHamplová, Mariecs
dc.contributor.authorNavrkalová, Jitkacs
dc.contributor.authorZlámalová Gargošová, Helenacs
dc.contributor.authorMravcová, Ludmilacs
dc.coverage.issue37cs
dc.coverage.volume9cs
dc.date.accessioned2025-03-28T07:43:00Z
dc.date.available2025-03-28T07:43:00Z
dc.date.issued2024-09-04cs
dc.description.abstractAgricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, potentially endangering agricultural crops and human health. This study aimed to evaluate various aspects related to the presence of pharmaceuticals in the lettuce-soil system, including bioconcentration factors (BCFs), translocation factors (TFs), ecotoxicological effects, the influence of biochar on the PhAC bioavailability, persistence in soil, and associated environmental and health risks. Lettuce (Lactuca sativa L.) was exposed to a mixture of 25 PhACs in two scenarios: initially contaminated soil (ranging from 0 to 10,000 ng center dot g(-1)) and soil irrigated with contaminated water (ranging from 0 to 1000 mu g center dot L-1) over a 28-day period. The findings revealed a diverse range of BCFs (0.068-3.7) and TFs (0.032-0.58), indicating the uptake and translocation potential of pharmaceuticals by lettuce. Significant ecotoxicological effects on L. sativa, including weight change and increased mortality, were observed (p < 0.05). Interestingly, biochar did not significantly affect PhAC uptake by L. sativa (p > 0.05), while it significantly influenced the soil degradation kinetics of 12 PhACs (p < 0.05). Additionally, the estimated daily intake of PhACs through the consumption of L. sativa suggested negligible health risks, although concerns arose regarding the potential health risks if other vegetable sources were similarly contaminated with trace residues. Furthermore, this study evaluated the environmental risk associated with the emergence of antimicrobial resistance (AMR) in soil, as medium to high. In conclusion, these findings highlight the multifaceted challenges posed by pharmaceutical contamination in agricultural environments and emphasize the importance of proactive measures to mitigate the associated risks to both environmental and human health.en
dc.formattextcs
dc.format.extent39065-39081cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS OMEGA. 2024, vol. 9, issue 37, p. 39065-39081.en
dc.identifier.doi10.1021/acsomega.4c05831cs
dc.identifier.issn2470-1343cs
dc.identifier.orcid0000-0002-3408-4383cs
dc.identifier.orcid0000-0002-8020-4948cs
dc.identifier.orcid0000-0001-8309-8012cs
dc.identifier.orcid0000-0003-1011-6616cs
dc.identifier.other189423cs
dc.identifier.researcheridG-9690-2018cs
dc.identifier.scopus25621742800cs
dc.identifier.urihttps://hdl.handle.net/11012/250685
dc.language.isoencs
dc.publisherAMER CHEMICAL SOCcs
dc.relation.ispartofACS OMEGAcs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsomega.4c05831cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2470-1343/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectpharmaceutical uptakeen
dc.subjectsoil-lettuce systemen
dc.subjectliquid chromatographyen
dc.subjectmass spectrometryen
dc.subjectecotoxicologyen
dc.subjectestimated daily intakeen
dc.subjectemergence of antimicrobial resistanceen
dc.titleAssessing Lettuce Exposure to a Multi-Pharmaceutical Mixture in Soil: Insights from LC-ESI-TQ Analysis and the Impact of Biochar on Pharmaceutical Bioavailabilityen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189423en
sync.item.dbtypeVAVen
sync.item.insts2025.03.28 08:43:00en
sync.item.modts2025.03.28 08:33:08en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé polymerní materiály a kompozitcs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Centrum materiálového výzkumucs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie materiálůcs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie a technologie ochrany životního prostředícs
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