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Item type:Item, Access status: Open Access , Cyclodextrin-Epichlorohydrin-Cyanoguanidine Polymer for Resveratrol Delivery to Enhance Human Chondrocyte Function in Cartilage Repair(American Chemical Society, 2026-05-06) Elmeligy, Mahmoud A.; Rasoulian, Forough; Kalantarifard, Shima; Filo, Juraj; Dinparvar, Sahar; Omer, Ahmed M.; Vojtová, Lucy; Nehrer, Stefan; Lacik, Igor; Heydari, AbolfazlWater-soluble beta-cyclodextrin-epichlorohydrin polymers (CDPs) are widely used in drug delivery and regenerative medicine. Herein, we report a novel beta-cyclodextrin-epichlorohydrin-cyanoguanidine polymer (CDPC) for resveratrol (RES) delivery in cartilage repair. Cyanoguanidine (CyG), a nitrogen-rich compound remaining nonprotonated at physiological pH, was incorporated at varying CyG/beta-CD ratios to modulate the polymer properties. Structural characterization was performed by NMR, FT-IR, and CHN analyses. Compared with CDP, CDPC exhibited enhanced RES encapsulation that was attributed to additional intramolecular interactions. Dynamic light scattering revealed nanosized complexes (18 nm for CDPC/RES vs 4 nm for CDP/RES) with a near-neutral surface charge. CDPC showed intrinsic antioxidant activity, which was further enhanced upon RES loading. Both CDP and CDPC were cytocompatible and were efficiently internalized by human chondrocytes. Moreover, the CDP/RES and CDPC/RES systems improved the chondrocyte metabolic activity and extracellular matrix deposition, highlighting their potential as promising carriers for cartilage repair and regeneration.Item type:Item, Access status: Open Access , Cyklická plasticita materiálů vyrobených technologií SLM(Vysoké učení technické v Brně. Fakulta strojního inženýrství) Nopová, Klára; Pantělejev, Libor; Fintová, Stanislava; Nový, FrantišekPředložené práce je zaměřena na zpracování Mg slitiny AZ91D technologií SLM. Postupným testováním a optimalizací jednotlivých procesních parametrů bylo dosaženo relativní hustoty materiálu >99 %, a to beze změny v chemickém složení slitiny. Díky velmi nízké porozitě a jemnozrnné mikrostruktuře materiálu dosáhla slitina poměrně vysokých mechanických charakteristik, Rm = 305 MPa, Rp0,2 = 181 MPa a A5,65 = 5,2 %. V oblasti cyklického zatěžování vykázala slitina po SLM procesu cyklickou stabilitu, přičemž v prvních několika cyklech bylo pozorováno cyklické změkčení v důsledku relaxace napětí a s následným cyklickým zpevnění v důsledku tvorby a kumulace dislokací. Na základě dat z vysokocyklové oblasti byla určena mez únavy (102,5 MPa), která úspěšně konkuruje extrudovaným Mg slitinám stejné třídy. Na základě fraktografické analýzy byla určena místa iniciace trhlin, a to ve všech případech v oblasti s pórem v blízkosti povrchu.Item type:Item, Access status: Open Access , Structural, electronic, and chemical manifestations of weak molecule-substrate coupling on Bi2Se3 compared with Ag, Au, and graphene(Elsevier, 2026-03-01) Čechal, Jan; Stará, Veronika; Kurowská, Anna; Blatnik, Matthias; Pravec, Daniel; Hrubá, Daniela; Kunc, Jan; Drasar, Cestmir; Planer, Jakub; Procházka, PavelModifying topological insulator (TI) surfaces with metal-organic layers offers a pathway to a material that displays the quantum anomalous Hall effect. However, knowledge of the molecular nanoarchitectonics on weakly interacting TI surfaces remains limited, which hinders the experimental realization of organic layers with the required properties. Here, we combine low-energy electron microscopy and diffraction, STM, XPS, and DFT calculations to investigate the adsorption of 4,4'-biphenyl-dicarboxylic acid (BDA) on the Bi2Se3(0001) and compare it with Ag(100), Ag(111), Au(111), and graphene substrates. We identify four manifestations of weak molecule-substrate coupling: (i) Upon deposition, the BDA molecule stays intact and is physisorbed. (ii) The intact nature of BDA is preserved at elevated temperatures. (iii) The electronic energy levels of BDA are decoupled from substrate polarization effects. (iv) There is a weak positional preference of the BDA molecular phase with respect to the substrate. Bi2Se3 exhibits uniquely weak structural, electronic, and chemical interactions with BDA, meeting all these points, whereas the other substrates fail to meet one or several of these points. These insights provide a quantitative framework for understanding weak molecule-substrate coupling across a range of 2D materials and metallic surfaces, informing the design of molecular architectures on nonmetallic substrates for quantum and functional nanomaterials with potential applications in quantum nanoelectronics.Item type:Item, Access status: Open Access , Thermal and filler concentration modulation of charge transport mechanism and dielectric properties in high-entropy oxide (CoCrFeNiMn)3O4-acrylic polymer composite(Springer Nature, 2026-02-04) Daradkeh, Samer Issa Abdel Razzaq; Alsoud, Ammar Awadallah Ahmad; Spusta, Tomáš; Pouchlý, Václav; Knápek, Alexandr; Tofel, Pavel; Sobola, DinaraThis study investigates the dielectric properties of polymer composites comprising an acrylic matrix and high-entropy oxide (HEO) (CoCrFeNiMn)3O4 filler. Single-phase HEO was synthesized via solid-state reaction followed by calcination at 850 degrees C (HEO-850). The research systematically examines the temperature- and concentration-dependent evolution of dielectric properties and charge transport mechanisms within these composite systems. Our findings reveal distinct correlations between filler concentration and dielectric performance enhancement. The unique properties of HEOs, stemming from their compositional complexity and structural characteristics, position these composite materials as promising candidates for advanced dielectric applications. The study elucidates fundamental parameters (temperature and filler concentration of HEO-850) governing the electrical behavior of HEO-polymer composites, providing insights into tailoring their properties for different technological applications.Item type:Item, Access status: Open Access , Concrete fatigue propagation from material to structure: Multiscale validation of a thermodynamically based discrete model on prisms and prestressed beams(Elsevier, 2026-04-15) Aguilar, Mario; Vořechovský, Miroslav; Baktheer, Abedulgader; Chudoba, RostislavFatigue assessment of concrete structures relies predominantly on empirical evidence from uniaxial cylinder tests, codified into structural design rules. Several continuum damage-plasticity models have been developed to capture fatigue-induced dissipative mechanisms. However, they do not explicitly resolve how damage propagates through the aggregate skeleton and translates into structural behavior. This study addresses this gap by integrating a thermodynamically based inter-aggregate constitutive law into a lattice discrete particle model that explicitly represents mesoscale concrete heterogeneity. The thermodynamic formulation inherently decomposes dissipated energy into contributions from distinct degradation mechanisms, enabling mechanism-specific fatigue characterization. The model is calibrated using macroscopic characteristics of monotonic and fatigue response of prisms under compression and validated against prestressed beam experiments under variable-amplitude fatigue loading. Simulations reproduce experimental trends of fatigue response in prestressed beams, revealing two key findings: (i) the obtained Sparks-Menzies relation persists across material and structural scales; (ii) damage dissipation emerges as a scale-consistent, load-level-independent indicator of fatigue capacity within a given stress configuration, offering a physically grounded alternative to empirical design criteria. The present high-fidelity model provides the basis for resolving the transition from meso-scale material behavior to macroscopic structural response, and establishes a foundation for future coarse-graining and time-scale acceleration strategies required for large structures and long fatigue lives.