Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair

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dc.contributor.authorJu, Xiaohuics
dc.contributor.authorJavorková, Eliškacs
dc.contributor.authorMichalička, Jancs
dc.contributor.authorPumera, Martincs
dc.coverage.issue20cs
dc.coverage.volume19cs
dc.date.accessioned2025-07-17T12:58:57Z
dc.date.available2025-07-17T12:58:57Z
dc.date.issued2025-05-13cs
dc.description.abstractCorneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.en
dc.formattextcs
dc.format.extent19095-19115cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS Nano (e-ISSN). 2025, vol. 19, issue 20, p. 19095-19115.en
dc.identifier.doi10.1021/acsnano.4c18874cs
dc.identifier.issn1936-086Xcs
dc.identifier.orcid0000-0001-6231-0061cs
dc.identifier.orcid0000-0001-5846-2951cs
dc.identifier.other198219cs
dc.identifier.researcheridF-2724-2010cs
dc.identifier.urihttps://hdl.handle.net/11012/255199
dc.language.isoencs
dc.publisherAmerican Chemical Societycs
dc.relation.ispartofACS Nano (e-ISSN)cs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsnano.4c18874cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1936-086X/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectsingle-atomen
dc.subjectcerium oxideen
dc.subjectnanoroboten
dc.subjectglucoseen
dc.subjectmesenchymal stem cellsen
dc.subjectcorneaen
dc.titleSingle-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repairen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-198219en
sync.item.dbtypeVAVen
sync.item.insts2025.07.17 14:58:57en
sync.item.modts2025.07.17 14:33:12en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav materiálových věd a inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Sdílená laboratoř RP1cs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
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Ústav materiálových věd a inženýrství
Energie budoucnosti a inovace
Sdílená laboratoř RP1