Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair
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Date
2025-05-13
Authors
Ju, Xiaohui
Javorková, Eliška
Michalička, Jan
Pumera, Martin
0000-0001-6231-0061Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
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Abstract
Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.
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Citation
ACS Nano (e-ISSN). 2025, vol. 19, issue 20, p. 19095-19115.
https://pubs.acs.org/doi/10.1021/acsnano.4c18874
https://pubs.acs.org/doi/10.1021/acsnano.4c18874
Document type
Peer-reviewed
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Published version
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Language of document
en