Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid

Abstract
Primary cilia, enriched in receptors and signaling molecules, serve as vital signaling hubs responsive to stimuli and are implicated in human diseases like retinopathies. TMEM107, localized to the transition zone of primary cilia, is linked to conditions such as Joubert and Meckel–Gruber syndromes, and its deficiency hinders cilia formation and early vertebrate eye development in retinal organoids.
Description
Citation
Life Science Alliance. 2023, vol. 6, issue 12, p. 1-16.
https://www.life-science-alliance.org/content/6/12/e202302073
Document type
Peer-reviewed
Document version
Published version
Date of access to the full text
Language of document
en
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Comittee
Date of acceptance
Defence
Result of defence
Document licence
Creative Commons Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
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