Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid

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dc.contributor.authorDubaic, Marijacs
dc.contributor.authorPešková, Luciecs
dc.contributor.authorHampl, Marekcs
dc.contributor.authorWeissová, Kamilacs
dc.contributor.authorCeliker, Canancs
dc.contributor.authorShylo, Natalya A.cs
dc.contributor.authorHrubá, Evacs
dc.contributor.authorKavková, Michaelacs
dc.contributor.authorZikmund, Tomášcs
dc.contributor.authorWeatherbee, Scott Donaldcs
dc.contributor.authorKaiser, Jozefcs
dc.contributor.authorBárta, Tomášcs
dc.contributor.authorBuchtová, Marcelacs
dc.coverage.issue12cs
dc.coverage.volume6cs
dc.date.issued2023-10-20cs
dc.description.abstractPrimary cilia, enriched in receptors and signaling molecules, serve as vital signaling hubs responsive to stimuli and are implicated in human diseases like retinopathies. TMEM107, localized to the transition zone of primary cilia, is linked to conditions such as Joubert and Meckel–Gruber syndromes, and its deficiency hinders cilia formation and early vertebrate eye development in retinal organoids.en
dc.formattextcs
dc.format.extent1-16cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationLife Science Alliance. 2023, vol. 6, issue 12, p. 1-16.en
dc.identifier.doi10.26508/lsa.202302073cs
dc.identifier.issn2575-1077cs
dc.identifier.orcid0000-0001-7435-9292cs
dc.identifier.orcid0000-0003-2948-5198cs
dc.identifier.orcid0000-0002-7397-125Xcs
dc.identifier.other184959cs
dc.identifier.researcheridG-9491-2014cs
dc.identifier.researcheridD-6800-2012cs
dc.identifier.scopus7402184758cs
dc.identifier.urihttp://hdl.handle.net/11012/245089
dc.language.isoencs
dc.publisherLife Science Alliancecs
dc.relation.ispartofLife Science Alliancecs
dc.relation.urihttps://www.life-science-alliance.org/content/6/12/e202302073cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2575-1077/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectTMEM107en
dc.subjectciliopathyen
dc.subjecteye developmenten
dc.subjectcell biologyen
dc.titleRole of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoiden
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-184959en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:48:25en
sync.item.modts2025.01.17 15:28:55en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav fyzikálního inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
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Ústav fyzikálního inženýrství
Pokročilé instrumentace a metody pro charakterizace materiálů