Synergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Wounds

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dc.contributor.authorDorazilová, Janacs
dc.contributor.authorMuchová, Johanacs
dc.contributor.authorŠmerková, Kristýnacs
dc.contributor.authorKočiová, Silviacs
dc.contributor.authorDiviš, Pavelcs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorVeselý, Radekcs
dc.contributor.authorPavliňáková, Veronikacs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorVojtová, Lucycs
dc.coverage.issue10cs
dc.coverage.volume10cs
dc.date.accessioned2020-12-08T23:56:06Z
dc.date.available2020-12-08T23:56:06Z
dc.date.issued2020-10-05cs
dc.description.abstractA highly porous scaffold is a desirable outcome in the field of tissue engineering. The porous structure mediates water-retaining properties that ensure good nutrient transportation as well as creates a suitable environment for cells. In this study, porous antibacterial collagenous scaffolds containing chitosan and selenium nanoparticles (SeNPs) as antibacterial agents were studied. The addition of antibacterial agents increased the application potential of the material for infected and chronic wounds. The morphology, swelling, biodegradation, and antibacterial activity of collagen-based scaffolds were characterized systematically to investigate the overall impact of the antibacterial additives. The additives visibly influenced the morphology, water retaining properties as well as the stability of the materials in the presence of collagenase enzymes. Even at concentrations as low as 5 ppm of SeNPs, modified polymeric scaffolds showed considerable inhibition activity towards Gram-positive bacterial strains such as Staphylococcus aureus and methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis in a dose-dependent manner.en
dc.formattextcs
dc.format.extent1971-1992cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNanomaterials. 2020, vol. 10, issue 10, p. 1971-1992.en
dc.identifier.doi10.3390/nano10101971cs
dc.identifier.issn2079-4991cs
dc.identifier.other165864cs
dc.identifier.urihttp://hdl.handle.net/11012/195615
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofNanomaterialscs
dc.relation.urihttps://www.mdpi.com/2079-4991/10/10/1971cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2079-4991/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjecttissue engineeringen
dc.subjectdrug releaseen
dc.subjectfreeze-dryingen
dc.subjectcollagenen
dc.subjectchitosanen
dc.subjectselenium nanoparticlesen
dc.subjectinfected burn injuriesen
dc.subjectbacteriaen
dc.subjectStaphylococcusen
dc.titleSynergistic Effect of Chitosan and Selenium Nanoparticles on Biodegradation and Antibacterial Properties of Collagenous Scaffolds Designed for Infected Burn Woundsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-165864en
sync.item.dbtypeVAVen
sync.item.insts2021.03.04 16:54:20en
sync.item.modts2021.03.04 16:14:46en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé biomateriálycs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie potravin a biotechnologiícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Charakterizace materiálů a pokročilé povlaky 1-06cs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav mikroelektronikycs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie materiálůcs
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Charakterizace materiálů a pokročilé povlaky 1-06
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Ústav chemie potravin a biotechnologií