Qualitative and quantitative analysis of leachables from dental composites under different extraction conditions using liquid chromatography coupled to mass spectrometry

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dc.contributor.authorFučík, Jancs
dc.contributor.authorKejík, Pavelcs
dc.contributor.authorBystřický, Zdeněkcs
dc.contributor.authorAmrichová, Annacs
dc.contributor.authorHamplová, Mariecs
dc.contributor.authorMravcová, Ludmilacs
dc.coverage.issue39cs
dc.coverage.volume141cs
dc.date.accessioned2025-02-03T14:38:15Z
dc.date.available2025-02-03T14:38:15Z
dc.date.issued2024-07-09cs
dc.description.abstractDental caries is the most widespread form of disease, affecting over 90% of the global population. Amalgam fillings, which have been in use for nearly two centuries, will face an European Union ban by 2025. Although photocomposite fillings are a suitable alternative, health concerns persist because of potential substance release into the oral cavity. This study aimed to evaluate the release of photoinitiator substances and monomers from dental materials into various solvents at different temperatures over 30 days. Cylindrical specimens of the composite resins were submerged in different extraction solutions and incubated at 37°C and 50°C. The findings demonstrated that both the extraction solvent and extraction temperature significantly influenced the quantity of leachables (p<0.05). Furthermore, most leachables were released within the initial days, although some monomers continued to elute for over 30 days. The estimated daily intake was calculated for the worst-case scenario, confirming the biocompatibility of the composite fillings. The weight loss of dental materials ranged up to 3.5% after 30 days, regardless of the extraction conditions and dental material (p>0.05). In conclusion, this study contributes to filling several research gaps in the field by addressing the biocompatibility of various dental materials through quantitative and qualitative analyses supported by statistical evaluation.en
dc.formattextcs
dc.format.extent14cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJournal of Applied Polymer Science. 2024, vol. 141, issue 39, 14 p.en
dc.identifier.doi10.1002/app.55987cs
dc.identifier.issn1097-4628cs
dc.identifier.orcid0000-0002-3408-4383cs
dc.identifier.orcid0000-0003-4561-7744cs
dc.identifier.orcid0000-0003-1011-6616cs
dc.identifier.other188924cs
dc.identifier.researcheridG-9690-2018cs
dc.identifier.scopus25621742800cs
dc.identifier.urihttps://hdl.handle.net/11012/249889
dc.language.isoencs
dc.publisherWiley Periodicals, LLC.cs
dc.relation.ispartofJournal of Applied Polymer Sciencecs
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/app.55987cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1097-4628/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectdental compositesen
dc.subjectmonomersen
dc.subjectleachablesen
dc.subjectcumulative extractionen
dc.subjectliquid chromatographyen
dc.subjectmass spectrometryen
dc.titleQualitative and quantitative analysis of leachables from dental composites under different extraction conditions using liquid chromatography coupled to mass spectrometryen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188924en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:15en
sync.item.modts2025.02.03 11:26:29en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie a technologie ochrany životního prostředícs
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