Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

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dc.contributor.authorKovář, Davidcs
dc.contributor.authorHubálek, Jaromírcs
dc.contributor.authorFohlerová, Zdenkacs
dc.contributor.authorMalá, Anetacs
dc.contributor.authorKalina, Michalcs
dc.contributor.authorJiřík, Radovancs
dc.contributor.authorHlaváček, Antoníncs
dc.contributor.authorSlabý, Ondřejcs
dc.contributor.authorSkládal, Petrcs
dc.contributor.authorFarka, Zdeněkcs
dc.contributor.authorMlčochová, Jitkacs
dc.contributor.authorStarčuk jr., Zenoncs
dc.coverage.issue1cs
dc.coverage.volume2017cs
dc.date.accessioned2020-08-04T10:59:31Z
dc.date.available2020-08-04T10:59:31Z
dc.date.issued2017-02-23cs
dc.description.abstractMagnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities and ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising -contrast probe.en
dc.formattextcs
dc.format.extent1-8cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationJOURNAL OF NANOMATERIALS. 2017, vol. 2017, issue 1, p. 1-8.en
dc.identifier.doi10.1155/2017/7859289cs
dc.identifier.issn1687-4110cs
dc.identifier.other134091cs
dc.identifier.urihttp://hdl.handle.net/11012/68359
dc.language.isoencs
dc.publisherHindawi Publishing Corporationcs
dc.relation.ispartofJOURNAL OF NANOMATERIALScs
dc.relation.urihttp://dx.doi.org/10.1155/2017/7859289cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1687-4110/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmagnetic nanoparticlesen
dc.subjectMRI imagingen
dc.titlePreparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imagingen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-134091en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 12:59:31en
sync.item.modts2020.08.04 12:44:06en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Centrum materiálového výzkumucs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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