Porous silica-doped calcium phosphate scaffolds prepared via in-situ foaming method

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dc.contributor.authorŠiška Virágová, Eliškacs
dc.contributor.authorNovotná, Lenkacs
dc.contributor.authorChlup, Zdeněkcs
dc.contributor.authorŠťastný, Přemyslcs
dc.contributor.authorŠárfy, Pavlínacs
dc.contributor.authorCihlář, Jaroslavcs
dc.contributor.authorKučírek, Martincs
dc.contributor.authorBenák, Leošcs
dc.contributor.authorStreit, Liborcs
dc.contributor.authorKocanda, Jancs
dc.contributor.authorSklenský, Jancs
dc.contributor.authorFilipovič, Milancs
dc.contributor.authorRepko, Martincs
dc.contributor.authorHampl, Alešcs
dc.contributor.authorKoutná, Irenacs
dc.contributor.authorČástková, Kláracs
dc.coverage.issue21cs
dc.coverage.volume50cs
dc.date.accessioned2025-02-03T14:47:45Z
dc.date.available2025-02-03T14:47:45Z
dc.date.issued2024-11-01cs
dc.description.abstractThe effect of silica (SiO2) addition (0 wt%-20 wt%) on the microstructural and mechanical properties, as well as the in vitro response of calcium phosphate scaffolds for potential application in bone tissue engineering (BTE) was investigated in this research. Scaffolds characterized by high porosity (77%-88 %) and interconnected spherical pores with a broad range of pore sizes (5-600 mu m) were fabricated using in-situ foaming method. Incorporated silica affected the phase transformation of hydroxyapatite (HA) to beta-tricalcium phosphate (beta-TCP) and led to the development of new crystalline silica-rich phases like silicocarnotite and wollastonite. The reinforcement of silica became apparent during the tests of mechanical properties. Scaffolds with 5 wt% of SiO2 exhibited compressive strength (1.13 MPa) higher than pure HA scaffolds (0.93 MPa). Bone bonding potential of the materials was tested in simulated body fluid (SBF), demonstrating this potential in silica-doped samples. Additionally, degradation experiments showed gradual material degradation, making it suitable for BTE applications. Furthermore, cell culture studies using human mesenchymal stromal cells (MSC) confirmed the scaffold's non- toxicity and provided insights into how the silica content influences cell viability, morphology, and osteogenic potential. The findings of this study offer valuable insights into the design and development of advanced scaffolds with tailored properties for effective BTE applications.en
dc.formattextcs
dc.format.extent41215-41227cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationCERAMICS INTERNATIONAL. 2024, vol. 50, issue 21, p. 41215-41227.en
dc.identifier.doi10.1016/j.ceramint.2024.07.433cs
dc.identifier.issn1873-3956cs
dc.identifier.orcid0009-0004-2648-6763cs
dc.identifier.orcid0000-0002-7445-342Xcs
dc.identifier.orcid0000-0003-1944-1159cs
dc.identifier.orcid0000-0002-4026-6845cs
dc.identifier.orcid0000-0002-6343-6659cs
dc.identifier.other189835cs
dc.identifier.researcheridG-8537-2014cs
dc.identifier.researcheridAAC-1273-2019cs
dc.identifier.researcheridH-7211-2014cs
dc.identifier.scopus7004377038cs
dc.identifier.urihttps://hdl.handle.net/11012/249965
dc.language.isoencs
dc.publisherELSEVIER SCI LTDcs
dc.relation.ispartofCERAMICS INTERNATIONALcs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0272884224033790?via%3Dihubcs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1873-3956/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectCalcium phosphatesen
dc.subjectSilicaen
dc.subjectIn-situ foamingen
dc.subjectMechanical strengthen
dc.subjectIn vitro responseen
dc.titlePorous silica-doped calcium phosphate scaffolds prepared via in-situ foaming methoden
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
eprints.grantNumberinfo:eu-repo/grantAgreement/MSM/LU/LUC23069cs
sync.item.dbidVAV-189835en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:47:45en
sync.item.modts2025.01.17 18:42:51en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. ÚMVI-odbor keramiky a polymerůcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé keramické materiálycs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilá multifunkční keramikacs
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ÚMVI-odbor keramiky a polymerů
Pokročilá multifunkční keramika
Pokročilé keramické materiály