Microfluidics chips fabrication techniques comparison
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Date
2024-11-20
Authors
Liu, Xiaocheng
Sun, Antao
Brodský, Jan
Gablech, Imrich
Lednický, Tomáš
Vopařilová, Petra
Zítka, Ondřej
Zeng, Wen
Neužil, Pavel
0000-0002-5656-3158Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
NATURE PORTFOLIO
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Abstract
This study investigates various microfluidic chip fabrication techniques, highlighting their applicability and limitations in the context of urgent diagnostic needs showcased by the COVID-19 pandemic. Through a detailed examination of methods such as computer numerical control milling of a polymethyl methacrylate, soft lithography for polydimethylsiloxane-based devices, xurography for glass-glass chips, and micromachining-based silicon-glass chips, we analyze each technique's strengths and trade-offs. Hence, we discuss the fabrication complexity and chip thermal properties, such as heating and cooling rates, which are essential features of chip utilization for a polymerase chain reaction. Our comparative analysis reveals critical insights into material challenges, design flexibility, and cost-efficiency, aiming to guide the development of robust and reliable microfluidic devices for healthcare and research. This work underscores the importance of selecting appropriate fabrication methods to optimize device functionality, durability, and production efficiency.
Description
Citation
Scientific Reports. 2024, vol. 14, issue 1, p. 1-13.
https://www.nature.com/articles/s41598-024-80332-2
https://www.nature.com/articles/s41598-024-80332-2
Document type
Peer-reviewed
Document version
Published version
Date of access to the full text
Language of document
en