Gas-Free Amino- and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Source

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dc.contributor.authorMessa, Francescocs
dc.contributor.authorPaparella, Andrea Nicolacs
dc.contributor.authorVeselý, Dominikcs
dc.contributor.authorKrajčovič, Jozefcs
dc.contributor.authorPapadia, Paridecs
dc.contributor.authorPerrone, Serenacs
dc.contributor.authorSalomone, Antoniocs
dc.coverage.issue24cs
dc.coverage.volume26cs
dc.date.issued2023-05-22cs
dc.description.abstractThe Pd-catalyzed amino- and alkoxycarbonylation of aryl iodides has been exploited, for the first time, in a bioinspired Deep Eutectic Solvent and under gas-free conditions, by using Mo(CO)(6) as the CO source. The method allows for the preparation of carboxylic amides and esters in high yields (up to 99 %), short reaction time (2 h) and under mild reaction conditions (80 degrees C), with a low catalyst loading (2.5 mol %). Noteworthy, in the case of N-hexylbenzamide, it has been demonstrated that both the catalyst and DES can be used for four consecutive runs, with a moderate decrease of catalytic efficiency. The methodology has been also applied to the preparation of an Active Pharmaceutical Ingredient used for the treatment of human scabies and lice.en
dc.formattextcs
dc.format.extent1-8cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationEUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2023, vol. 26, issue 24, p. 1-8.en
dc.identifier.doi10.1002/ejoc.202300309cs
dc.identifier.issn1434-193Xcs
dc.identifier.orcid0000-0002-8764-7653cs
dc.identifier.orcid0000-0002-7495-1787cs
dc.identifier.other184175cs
dc.identifier.urihttp://hdl.handle.net/11012/244939
dc.language.isoencs
dc.publisherWiley-VCHcs
dc.relation.ispartofEUROPEAN JOURNAL OF ORGANIC CHEMISTRYcs
dc.relation.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300309cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1434-193X/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectalkoxycarbonylationen
dc.subjectaminocarbonylationen
dc.subjectPd-catalysisen
dc.subjectdeep eutectic solventen
dc.subjectmolybdenum hexacarbonylen
dc.titleGas-Free Amino- and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Sourceen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-184175en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:12en
sync.item.modts2025.01.17 16:48:59en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie a technologie ochrany životního prostředícs
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