Gas-Free Amino- and Alkoxycarbonylation of Aryl Iodides in a Bioinspired Deep Eutectic Solvent with Mo(CO)6 as a Safe CO Source
Loading...
Date
2023-05-22
Authors
Messa, Francesco
Paparella, Andrea Nicola
Veselý, Dominik
Krajčovič, Jozef
Papadia, Paride
Perrone, Serena
Salomone, Antonio
0000-0002-8764-7653Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-VCH
Altmetrics
Abstract
The Pd-catalyzed amino- and alkoxycarbonylation of aryl iodides has been exploited, for the first time, in a bioinspired Deep Eutectic Solvent and under gas-free conditions, by using Mo(CO)(6) as the CO source. The method allows for the preparation of carboxylic amides and esters in high yields (up to 99 %), short reaction time (2 h) and under mild reaction conditions (80 degrees C), with a low catalyst loading (2.5 mol %). Noteworthy, in the case of N-hexylbenzamide, it has been demonstrated that both the catalyst and DES can be used for four consecutive runs, with a moderate decrease of catalytic efficiency. The methodology has been also applied to the preparation of an Active Pharmaceutical Ingredient used for the treatment of human scabies and lice.
Description
Citation
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2023, vol. 26, issue 24, p. 1-8.
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300309
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/ejoc.202300309
Document type
Peer-reviewed
Document version
Published version
Date of access to the full text
Language of document
en
Study field
Comittee
Date of acceptance
Defence
Result of defence
Document licence
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/