Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair

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dc.contributor.authorOliver Urrutia, Carolinacs
dc.contributor.authorKashimbetova, Adeliacs
dc.contributor.authorSlámečka, Karelcs
dc.contributor.authorCasas Luna, Marianocs
dc.contributor.authorMatula, Jancs
dc.contributor.authorKoledová, Zuzanacs
dc.contributor.authorKaiser, Jozefcs
dc.contributor.authorČelko, Ladislavcs
dc.contributor.authorMontufar Jimenez, Edgar Benjamincs
dc.coverage.issue1cs
dc.coverage.volume166cs
dc.date.accessioned2025-04-30T11:56:23Z
dc.date.available2025-04-30T11:56:23Z
dc.date.issued2025-01-01cs
dc.description.abstractThis study introduces the first fabrication of porous titanium/hydroxyapatite interpenetrating phase composites through an innovative processing method. The approach combines additive manufacturing of a customized titanium skeleton with the infiltration of an injectable hydroxyapatite foam, followed by in situ foam hardening at physiological temperature. This biomimetic process circumvents ceramic sintering and metal casting, effectively avoiding the formation of secondary phases that can impair mechanical performance. Hydroxyapatite foams, prepared using two foaming agents (polysorbate 80 and gelatine), significantly reinforce the titanium skeleton while preserving the microstructural characteristics essential for osteoinductive properties. The strengthening mechanisms rely on the conformation of the foams to the titanium surface, thereby enabling stable mechanical interlocking and effective interfacial stress transfer. This, combined with the mechanical constriction of phases, enhances damage tolerance and mechanical reliability of the interpenetrating phase composites. In addition, the interpenetrating phase composites feature a network of concave pores with an optimal size for bone repair, support human osteoblast proliferation, and exhibit mechanical properties compatible with bone, offering a promising solution for the efficient and personalized reconstruction of large bone defects. The results demonstrate a significant advancement in composite fabrication, integrating the benefits of additive manufacturing for bone repair with the osteogenic capacity of calcium phosphate ceramics.en
dc.formattextcs
dc.format.extent1-11cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBIOMATERIALS ADVANCES. 2025, vol. 166, issue 1, p. 1-11.en
dc.identifier.doi10.1016/j.bioadv.2024.214079cs
dc.identifier.issn2772-9508cs
dc.identifier.orcid0000-0002-1945-2563cs
dc.identifier.orcid0000-0001-8847-075Xcs
dc.identifier.orcid0000-0002-3449-1325cs
dc.identifier.orcid0000-0003-3334-956Xcs
dc.identifier.orcid0000-0002-7397-125Xcs
dc.identifier.orcid0000-0003-0264-3483cs
dc.identifier.orcid0000-0002-8122-4000cs
dc.identifier.other193664cs
dc.identifier.researcheridD-9475-2012cs
dc.identifier.researcheridAAB-5781-2021cs
dc.identifier.researcheridD-6800-2012cs
dc.identifier.researcheridD-6870-2012cs
dc.identifier.researcheridF-8040-2016cs
dc.identifier.scopus16242487800cs
dc.identifier.scopus57053564300cs
dc.identifier.scopus7402184758cs
dc.identifier.scopus25621022900cs
dc.identifier.scopus23397943300cs
dc.identifier.urihttps://hdl.handle.net/11012/250905
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofBIOMATERIALS ADVANCEScs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2772950824003224cs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2772-9508/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectTitaniumen
dc.subjectHydroxyapatiteen
dc.subjectInfiltrationen
dc.subjectSelf-hardeningen
dc.subjectCeramic matrix compositeen
dc.subjectBone repairen
dc.titlePorous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repairen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-193664en
sync.item.dbtypeVAVen
sync.item.insts2025.04.30 13:56:23en
sync.item.modts2025.04.30 13:33:31en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé povlakycs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav fyzikálního inženýrstvícs
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