Amine modification of calcium phosphate by low-pressure plasma for bone regeneration

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dc.contributor.authorKodama, Joecs
dc.contributor.authorHarumningtyas, Anjar Anggrainics
dc.contributor.authorIto, Tomokocs
dc.contributor.authorMichlíček, Miroslavcs
dc.contributor.authorSugimoto, Satoshics
dc.contributor.authorKita, Hidekazucs
dc.contributor.authorChijimatsu, Ryotacs
dc.contributor.authorUkon, Yuichirocs
dc.contributor.authorKushioka, Junichics
dc.contributor.authorOkada, Rintarocs
dc.contributor.authorKamatani, Takashics
dc.contributor.authorHashimoto, Kunihikocs
dc.contributor.authorTateiwa, Daisukecs
dc.contributor.authorTsukazaki, Hiroyukics
dc.contributor.authorNakagawa, Shinichics
dc.contributor.authorTakenaka, Shotacs
dc.contributor.authorMakino, Takahirocs
dc.contributor.authorSakai, Yusukecs
dc.contributor.authorNečas, Davidcs
dc.contributor.authorZajíčková, Lenkacs
dc.contributor.authorHamaguchi, Satoshics
dc.contributor.authorKaito, Takashics
dc.coverage.issue1cs
dc.coverage.volume11cs
dc.date.accessioned2021-12-15T11:54:55Z
dc.date.available2021-12-15T11:54:55Z
dc.date.issued2021-09-01cs
dc.description.abstractRegeneration of large bone defects caused by trauma or tumor resection remains one of the biggest challenges in orthopedic surgery. Because of the limited availability of autograft material, the use of artificial bone is prevalent; however, the primary role of currently available artificial bone is restricted to acting as a bone graft extender owing to the lack of osteogenic ability. To explore whether surface modification might enhance artificial bone functionality, in this study we applied low-pressure plasma technology as next-generation surface treatment and processing strategy to chemically (amine) modify the surface of beta-tricalcium phosphate (beta-TCP) artificial bone using a CH4/N-2/He gas mixture. Plasma-treated beta-TCP exhibited significantly enhanced hydrophilicity, facilitating the deep infiltration of cells into interconnected porous beta-TCP. Additionally, cell adhesion and osteogenic differentiation on the plasma-treated artificial bone surfaces were also enhanced. Furthermore, in a rat calvarial defect model, the plasma treatment afforded high bone regeneration capacity. Together, these results suggest that amine modification of artificial bone by plasma technology can provide a high osteogenic ability and represents a promising strategy for resolving current clinical limitations regarding the use of artificial bone.en
dc.formattextcs
dc.format.extent1-15cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific Reports. 2021, vol. 11, issue 1, p. 1-15.en
dc.identifier.doi10.1038/s41598-021-97460-8cs
dc.identifier.issn2045-2322cs
dc.identifier.other174111cs
dc.identifier.urihttp://hdl.handle.net/11012/203224
dc.language.isoencs
dc.publisherNature Portfoliocs
dc.relation.ispartofScientific Reportscs
dc.relation.urihttps://www.nature.com/articles/s41598-021-97460-8cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2045-2322/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectmesenchymal stem-cellsen
dc.subjectosteoblast differentiationen
dc.subjectintegrin bindingen
dc.subjectin-vitroen
dc.subjectadhesionen
dc.subjectfibronectinen
dc.subjectpolymerizationen
dc.subjectspecificityen
dc.subjecttopographyen
dc.subjectactivationen
dc.titleAmine modification of calcium phosphate by low-pressure plasma for bone regenerationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-174111en
sync.item.dbtypeVAVen
sync.item.insts2022.01.02 20:54:56en
sync.item.modts2022.01.02 20:15:25en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Vývoj metod analýzy a měřenícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé nízkodimenzionální nanomateriálycs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav teoretické a experimentální elektrotechnikycs
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Pokročilé nízkodimenzionální nanomateriály
Vývoj metod analýzy a měření
Ústav teoretické a experimentální elektrotechniky