Influence of liposomal platinum cytostatics on cancer cells by voltammetric methods

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dc.contributor.authorSedláčková, Eliškacs
dc.contributor.authorLaníková, Petracs
dc.contributor.authorHynek, Davidcs
dc.contributor.authorKrejčová, Ludmilacs
dc.contributor.authorBuchtelová, Hanacs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorAdam, Vojtěchcs
dc.date.accessioned2019-06-20T06:10:28Z
dc.date.available2019-06-20T06:10:28Z
dc.date.issued2018-03-31cs
dc.description.abstractAim of this work deals with closing of cisplatin into liposomes, the study of their stability and interaction with cancer cell lines. Commercial cisplatin cytostatic was encapsulated into three types of liposomes (L8, L10 and L15) of a different chemical composition. Each of liposomes had different ability to close cytostatic. L8 differs from L10 by containing cholesterol. In despite of L10 and L8, L15 liposome contains a synthetic 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (C41H78NO8P) – DOPE, which is generally found in cell membranes. The size of the liposomes was characterized by Dynamic Light Scattering (DLS). The amount of Pt-drug in liposomes was verified by electrochemical determination. Their stability was observed by differential pulse voltammetry (DPV). These studies also demonstrated, that the cisplatin is stable in physiological solution for at least 24 hours, which making it a suitable medium storage for this drug. Finally, the encapsulated cisplatin was applied to cancer cell lines and their viability was observed by MTT assay.en
dc.formattextcs
dc.format.extent548-553cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNANOCON 2017. 2018, p. 548-553.en
dc.identifier.isbn978-80-87294-81-9cs
dc.identifier.other148684cs
dc.identifier.urihttp://hdl.handle.net/11012/178375
dc.language.isoencs
dc.publisherTANGERcs
dc.relation.ispartofNANOCON 2017cs
dc.relation.urihttps://nanocon2017.tanger.cz/cz/cs
dc.rights(C) TANGERcs
dc.rights.accessopenAccesscs
dc.subjectCisplatinen
dc.subjectliposomesen
dc.subjectelectrochemistryen
dc.subjectdifferential pulse voltammetryen
dc.subjectcancer cell linesen
dc.titleInfluence of liposomal platinum cytostatics on cancer cells by voltammetric methodsen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-148684en
sync.item.dbtypeVAVen
sync.item.insts2020.05.16 00:56:56en
sync.item.modts2020.05.16 00:14:39en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav biomedicínského inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. oddělení-MEL-SIXcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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