In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

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dc.contributor.authorRebenda, Davidcs
dc.contributor.authorRanuša, Matúšcs
dc.contributor.authorČípek, Pavelcs
dc.contributor.authorToropitsyn, Evgeniycs
dc.contributor.authorVrbka, Martincs
dc.coverage.issue1cs
dc.coverage.volume11cs
dc.date.accessioned2023-03-16T15:52:58Z
dc.date.available2023-03-16T15:52:58Z
dc.date.issued2023-01-01cs
dc.description.abstractDegradation of the articular cartilage (AC) structure due to osteoarthritis significantly influences its friction and lubrication mechanisms. Injection with exogenous hyaluronic acid (HA) is one of the ways to slow down the progress of these changes. The present paper aims to determine the effect of HA on the friction and lubrication processes of the synovial joint model. The main emphasis is placed on the effect of HA molecular weight (MW) on the coefficient of friction (COF) and the interactions between HA and other constituents of synovial fluid (SF). Frictional measurements between the AC surface and the glass were performed with simultaneous in situ observation of the contact zone by fluorescence microscopy. Using this methodology, a decrease in AC COF with an increase in the fluorescence intensity emitted from contact with HA was observed, while the phenomenon was found to be MW-dependent. These findings demonstrate that high-MW HA is more effective within a resumption of healthy AC lubrication due to a better adhesion to the AC surface.en
dc.formattextcs
dc.format.extent15cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationLubricants. 2023, vol. 11, issue 1, 15 p.en
dc.identifier.doi10.3390/lubricants11010012cs
dc.identifier.issn2075-4442cs
dc.identifier.other182273cs
dc.identifier.urihttp://hdl.handle.net/11012/209205
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofLubricantscs
dc.relation.urihttps://www.mdpi.com/2075-4442/11/1/12cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2075-4442/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectarticular cartilageen
dc.subjectfrictionen
dc.subjectlubricationen
dc.subjecthyaluronic aciden
dc.subjectviscosupplementationen
dc.titleIn Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubricationen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-182273en
sync.item.dbtypeVAVen
sync.item.insts2023.03.16 16:52:58en
sync.item.modts2023.03.16 16:14:42en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav konstruovánícs
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