The Effect of the Thermosensitive Biodegradable PLGA–PEG–PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement

dc.contributor.authorVojtová, Lucycs
dc.contributor.authorMichlovská, Lenkacs
dc.contributor.authorHlináková, Kristýnacs
dc.contributor.authorZbončák, Marekcs
dc.contributor.authorTrunec, Martincs
dc.contributor.authorČástková, Kláracs
dc.contributor.authorKrtička, Milancs
dc.contributor.authorPavliňáková, Veronikacs
dc.contributor.authorPoláček, Petrcs
dc.contributor.authorDzurov, Matejcs
dc.contributor.authorLukášová, Věracs
dc.contributor.authorRampichová, Michalacs
dc.contributor.authorSuchý, Tomášcs
dc.contributor.authorSedláček, Radekcs
dc.contributor.authorGinebra, Maria-Paucs
dc.contributor.authorMontufar Jimenez, Edgar Benjamincs
dc.coverage.issue2cs
dc.coverage.volume20cs
dc.date.issued2019-01-17cs
dc.description.abstractThe current limitations of calcium phosphate cements (CPCs) used in the field of bone regeneration consist of their brittleness, low injectability, disintegration in body fluids and low biodegradability. Moreover, no method is currently available to measure the setting time of CPCs in correlation with the evolution of the setting reaction. The study proposes that it is possible to improve and tune the properties of CPCs via the addition of a thermosensitive, biodegradable, thixotropic copolymer based on poly(lactic acid), poly(glycolic acid) and poly(ethylene glycol) (PLGA-PEG-PLGA) which undergoes gelation under physiological conditions. The setting times of alpha-tricalcium phosphate (-TCP) mixed with aqueous solutions of PLGA-PEG-PLGA determined by means of time-sweep curves revealed a lag phase during the dissolution of the -TCP particles. The magnitude of the storage modulus at lag phase depends on the liquid to powder ratio, the copolymer concentration and temperature. A sharp increase in the storage modulus was observed at the time of the precipitation of calcium deficient hydroxyapatite (CDHA) crystals, representing the loss of paste workability. The PLGA-PEG-PLGA copolymer demonstrates the desired pseudoplastic rheological behaviour with a small decrease in shear stress and the rapid recovery of the viscous state once the shear is removed, thus preventing CPC phase separation and providing good cohesion. Preliminary cytocompatibility tests performed on human mesenchymal stem cells proved the suitability of the novel copolymer/-TCP for the purposes of mini-invasive surgery.en
dc.formattextcs
dc.format.extent1-21cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Molecular Sciences. 2019, vol. 20, issue 2, p. 1-21.en
dc.identifier.doi10.3390/ijms20020391cs
dc.identifier.issn1422-0067cs
dc.identifier.orcid0000-0001-5281-7045cs
dc.identifier.orcid0000-0002-7963-1715cs
dc.identifier.orcid0000-0002-6781-1858cs
dc.identifier.orcid0000-0002-6463-2985cs
dc.identifier.orcid0000-0001-6402-7518cs
dc.identifier.orcid0000-0002-6343-6659cs
dc.identifier.orcid0000-0002-4694-298Xcs
dc.identifier.orcid0000-0003-0879-6851cs
dc.identifier.orcid0000-0003-0620-8817cs
dc.identifier.orcid0000-0002-8122-4000cs
dc.identifier.other155140cs
dc.identifier.researcheridD-7762-2012cs
dc.identifier.researcheridB-1133-2014cs
dc.identifier.researcheridA-7957-2009cs
dc.identifier.researcheridB-3167-2014cs
dc.identifier.researcheridD-9873-2012cs
dc.identifier.researcheridF-8040-2016cs
dc.identifier.scopus12039667200cs
dc.identifier.scopus25621760100cs
dc.identifier.scopus6603323803cs
dc.identifier.scopus56108279900cs
dc.identifier.scopus22938742400cs
dc.identifier.scopus23397943300cs
dc.identifier.urihttp://hdl.handle.net/11012/138399
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofInternational Journal of Molecular Sciencescs
dc.relation.urihttp://www.mdpi.com/1422-0067/20/2/391cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1422-0067/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectinjectable bone cementsen
dc.subjectthixotropicen
dc.subjectrheologyen
dc.subjectmorphologyen
dc.subjectkineticsen
dc.subjectbiocompatibilityen
dc.titleThe Effect of the Thermosensitive Biodegradable PLGA–PEG–PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cementen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-155140en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:15en
sync.item.modts2025.01.17 15:18:06en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie materiálůcs
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav materiálových věd a inženýrstvícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Středoevropský technologický institut VUTcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé keramické materiálycs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé polymerní materiály a kompozitcs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé povlakycs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé biomateriálycs
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
The Effect of the Thermosensitive Biodegradable PLGAPEGPLGA Copolymer on the Rheological Structural and Mechanical Properties.pdf
Size:
4.59 MB
Format:
Adobe Portable Document Format
Description:
file The Effect of the Thermosensitive Biodegradable PLGAPEGPLGA Copolymer on the Rheological Structural and Mechanical Properties.pdf