Magnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Cancer

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dc.contributor.authorUssia, Martinacs
dc.contributor.authorUrso, Mariocs
dc.contributor.authorKratochvílová, Monikacs
dc.contributor.authorNavrátil, Jiřícs
dc.contributor.authorBalvan, Jancs
dc.contributor.authorMayorga-Martinez, Carmen C.cs
dc.contributor.authorVyskočil, Jancs
dc.contributor.authorMasařík, Michalcs
dc.contributor.authorPumera, Martincs
dc.coverage.issue17cs
dc.coverage.volume19cs
dc.date.accessioned2023-08-01T10:58:32Z
dc.date.available2023-08-01T10:58:32Z
dc.date.issued2023-04-01cs
dc.description.abstractProstate cancer is the most commonly diagnosed tumor disease in men, and its treatment is still a big challenge in standard oncology therapy. Magnetically actuated microrobots represent the most promising technology in modern nanomedicine, offering the advantage of wireless guidance, effective cell penetration, and non-invasive actuation. Here, new biodegradable magnetically actuated zinc/cystine-based microrobots for in situ treatment of prostate cancer cells are reported. The microrobots are fabricated via metal-ion-mediated self-assembly of the amino acid cystine encapsulating superparamagnetic Fe3O4 nanoparticles (NPs) during the synthesis, which allows their precise manipulation by a rotating magnetic field. Inside the cells, the typical enzymatic reducing environment favors the disassembly of the aminoacidic chemical structure due to the cleavage of cystine disulfide bonds and disruption of non-covalent interactions with the metal ions, as demonstrated by in vitro experiments with reduced nicotinamide adenine dinucleotide (NADH). In this way, the cystine microrobots served for site-specific delivery of Zn2+ ions responsible for tumor cell killing via a "Trojan horse effect". This work presents a new concept of cell internalization exploiting robotic systems' self-degradation, proposing a step forward in non-invasive cancer therapy.en
dc.formattextcs
dc.format.extent12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationSmall. 2023, vol. 19, issue 17, 12 p.en
dc.identifier.doi10.1002/smll.202208259cs
dc.identifier.issn1613-6829cs
dc.identifier.orcid0000-0002-3248-6725cs
dc.identifier.orcid0000-0001-7993-8138cs
dc.identifier.orcid0000-0003-1172-7195cs
dc.identifier.orcid0000-0001-5846-2951cs
dc.identifier.other183952cs
dc.identifier.researcheridD-9920-2012cs
dc.identifier.researcheridF-2724-2010cs
dc.identifier.urihttp://hdl.handle.net/11012/213673
dc.language.isoencs
dc.publisherWILEY-V C H VERLAG GMBHcs
dc.relation.ispartofSmallcs
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/smll.202208259cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1613-6829/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectcysteineen
dc.subjectmagnetic actuationen
dc.subjectmicromotorsen
dc.subjectnanorobotsen
dc.subjectself-propulsionen
dc.subjecttumorsen
dc.titleMagnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Canceren
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183952en
sync.item.dbtypeVAVen
sync.item.insts2023.08.01 12:58:32en
sync.item.modts2023.08.01 12:20:24en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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