A low-cost picowatt calorimeter using a flexible printed circuit board
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Date
2025-03-27
Authors
Zhu, Hanliang
Zhang, Yue
Wang, Lan
Brodský, Jan
Gablech, Imrich
Feng, Jianguo
Yan, Qi-Long
Yang, Shujie
Lee, Luke P.
Neužil, Pavel
0000-0002-5656-3158Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Portfolio
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Abstract
Calorimetry is crucial in biology, chemistry, physics, and pharmaceutical research, enabling the detection of heat changes at nanowatt and picowatt levels. However, traditional calorimetry systems are often limited by high costs and complex fabrication processes. Here, we reduce the cost and fabrication complexity of microcalorimeters by utilizing widely available flexible printed circuit manufacturing processes. This device achieves temperature and power resolutions of 6 K and 654pW in vacuum. Its feasibility is validated across a wide range of measurements, including salt crystallization, protein crystallization, and cellular metabolism. Our concept enhances the accessibility of microcalorimeters for high-resolution thermal analysis, which is challenging for conventional calorimeters.
Description
Citation
NATURE COMMUNICATIONS. 2025, vol. 16, issue March, p. 1-13.
https://www.nature.com/articles/s41467-025-58025-9
https://www.nature.com/articles/s41467-025-58025-9
Document type
Peer-reviewed
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Published version
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Language of document
en
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Date of acceptance
Defence
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/