Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution
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Date
2024-12-01
Authors
Drotárová, Lenka
Slámečka, Karel
Bálint, Tomáš
Remešová, Michaela
Hudák, Radovan
Živčák, Jozef
Schnitzer, Marek
Čelko, Ladislav
Montufar Jimenez, Edgar Benjamin
0009-0003-7028-5427Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
KEAI PUBLISHING LTD
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Abstract
Biodegradable magnesium implants offer a solution for bone repair without the need for implant removal. However, concerns persist regarding peri-implant gas accumulation, which has limited their widespread clinical acceptance. Consequently, there is a need to minimise the mass of magnesium to reduce the total volume of gas generated around the implants. Incorporating porosity is a direct approach to reducing the mass of the implants, but it also decreases the strength and degradation resistance. This study demonstrates that the infiltration of a calcium phosphate cement into an additively manufactured WE43 Mg alloy scaffold with 75 % porosity, followed by hydrothermal treatment, yields biodegradable magnesium/hydroxyapatite interpenetrating phase composites that generate an order of magnitude less hydrogen gas during degradation than WE43 scaffolds. The enhanced degradation resistance results from magnesium passivation, allowing osteoblast proliferation in indirect contact with composites. Additionally, the composites exhibit a compressive strength 1.8 times greater than that of the scaffolds, falling within the upper range of the compressive strength of cancellous bone. These results emphasise the potential of the new biodegradable interpenetrating phase composites for the fabrication of temporary osteosynthesis devices. Optimizing cement hardening and magnesium passivation during hydrothermal processing is crucial for achieving both high compressive strength and low degradation rate.
Description
Citation
Bioactive Materials. 2024, vol. 42, issue 12, p. 519-530.
https://www.sciencedirect.com/science/article/pii/S2452199X24003876
https://www.sciencedirect.com/science/article/pii/S2452199X24003876
Document type
Peer-reviewed
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Published version
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Language of document
en