A novel ruthenium based coordination compound against pathogenic bacteria
dc.contributor.author | Sur, Vishma Pratap | cs |
dc.contributor.author | Mazumdar, Aninda | cs |
dc.contributor.author | Kopel, Pavel | cs |
dc.contributor.author | Mukherjee, S. | cs |
dc.contributor.author | Vítek, Petr | cs |
dc.contributor.author | Michálková, Hana | cs |
dc.contributor.author | Vaculovičová, Markéta | cs |
dc.contributor.author | Moulick, Amitava | cs |
dc.coverage.issue | 7 | cs |
dc.coverage.volume | 21 | cs |
dc.date.accessioned | 2020-08-04T11:03:52Z | |
dc.date.available | 2020-08-04T11:03:52Z | |
dc.date.issued | 2020-04-10 | cs |
dc.description.abstract | The current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4. | en |
dc.format | text | cs |
dc.format.extent | 1-18 | cs |
dc.format.mimetype | application/pdf | cs |
dc.identifier.citation | International Journal of Molecular Sciences. 2020, vol. 21, issue 7, p. 1-18. | en |
dc.identifier.doi | 10.3390/ijms21072656 | cs |
dc.identifier.issn | 1422-0067 | cs |
dc.identifier.other | 164290 | cs |
dc.identifier.uri | http://hdl.handle.net/11012/189392 | |
dc.language.iso | en | cs |
dc.publisher | MDPI | cs |
dc.relation.ispartof | International Journal of Molecular Sciences | cs |
dc.relation.uri | https://www.mdpi.com/1422-0067/21/7/2656 | cs |
dc.rights | Creative Commons Attribution 4.0 International | cs |
dc.rights.access | openAccess | cs |
dc.rights.sherpa | http://www.sherpa.ac.uk/romeo/issn/1422-0067/ | cs |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | cs |
dc.subject | coordination compound | en |
dc.subject | antimicrobial compound | en |
dc.subject | ruthenium | en |
dc.subject | benzimidazole | en |
dc.subject | SEM | en |
dc.subject | EDS | en |
dc.title | A novel ruthenium based coordination compound against pathogenic bacteria | en |
dc.type.driver | article | en |
dc.type.status | Peer-reviewed | en |
dc.type.version | publishedVersion | en |
sync.item.dbid | VAV-164290 | en |
sync.item.dbtype | VAV | en |
sync.item.insts | 2020.12.07 16:55:53 | en |
sync.item.modts | 2020.12.07 16:14:18 | en |
thesis.grantor | Vysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástroje | cs |
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