A novel ruthenium based coordination compound against pathogenic bacteria

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dc.contributor.authorSur, Vishma Pratapcs
dc.contributor.authorMazumdar, Anindacs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorMukherjee, S.cs
dc.contributor.authorVítek, Petrcs
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorVaculovičová, Markétacs
dc.contributor.authorMoulick, Amitavacs
dc.coverage.issue7cs
dc.coverage.volume21cs
dc.date.issued2020-04-10cs
dc.description.abstractThe current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4.en
dc.description.abstractThe current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020, vol. 21, issue 7, p. 1-18.en
dc.identifier.doi10.3390/ijms21072656cs
dc.identifier.issn1661-6596cs
dc.identifier.orcid0000-0002-1175-7194cs
dc.identifier.orcid0000-0002-4985-7115cs
dc.identifier.orcid0000-0003-4216-9544cs
dc.identifier.orcid0000-0002-6771-1304cs
dc.identifier.orcid0000-0001-5769-6748cs
dc.identifier.other164290cs
dc.identifier.researcheridE-5711-2012cs
dc.identifier.researcheridE-5583-2016cs
dc.identifier.researcheridI-9677-2016cs
dc.identifier.scopus6603604023cs
dc.identifier.scopus55783172600cs
dc.identifier.urihttp://hdl.handle.net/11012/189392
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofINTERNATIONAL JOURNAL OF MOLECULAR SCIENCEScs
dc.relation.urihttps://www.mdpi.com/1422-0067/21/7/2656cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1661-6596/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectcoordination compounden
dc.subjectantimicrobial compounden
dc.subjectrutheniumen
dc.subjectbenzimidazoleen
dc.subjectSEMen
dc.subjectEDSen
dc.subjectcoordination compound
dc.subjectantimicrobial compound
dc.subjectruthenium
dc.subjectbenzimidazole
dc.subjectSEM
dc.subjectEDS
dc.titleA novel ruthenium based coordination compound against pathogenic bacteriaen
dc.title.alternativeA novel ruthenium based coordination compound against pathogenic bacteriaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164290en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 15:16:35en
sync.item.modts2025.10.14 09:33:50en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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