A novel ruthenium based coordination compound against pathogenic bacteria

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dc.contributor.authorSur, Vishma Pratapcs
dc.contributor.authorMazumdar, Anindacs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorMukherjee, S.cs
dc.contributor.authorVítek, Petrcs
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorVaculovičová, Markétacs
dc.contributor.authorMoulick, Amitavacs
dc.coverage.issue7cs
dc.coverage.volume21cs
dc.date.accessioned2020-08-04T11:03:52Z
dc.date.available2020-08-04T11:03:52Z
dc.date.issued2020-04-10cs
dc.description.abstractThe current epidemic of antibiotic-resistant infections urges to develop alternatives to less-effective antibiotics. To assess anti-bacterial potential, a novel coordinate compound (RU-S4) was synthesized using ruthenium-Schiff base-benzimidazole ligand, where ruthenium chloride was used as the central atom. RU-S4 was characterized by scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy. Antibacterial effect of RU-S4 was studied against Staphylococcus aureus (NCTC 8511), vancomycin-resistant Staphylococcus aureus (VRSA) (CCM 1767), methicillin-resistant Staphylococcus aureus (MRSA) (ST239: SCCmecIIIA), and hospital isolate Staphylococcus epidermidis. The antibacterial activity of RU-S4 was checked by growth curve analysis and the outcome was supported by optical microscopy imaging and fluorescence LIVE/DEAD cell imaging. In vivo (balb/c mice) infection model prepared with VRSA (CCM 1767) and treated with RU-S4. In our experimental conditions, all infected mice were cured. The interaction of coordination compound with bacterial cells were further confirmed by cryo-scanning electron microscope (Cryo-SEM). RU-S4 was completely non-toxic against mammalian cells and in mice and subsequently treated with synthesized RU-S4.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Molecular Sciences. 2020, vol. 21, issue 7, p. 1-18.en
dc.identifier.doi10.3390/ijms21072656cs
dc.identifier.issn1422-0067cs
dc.identifier.other164290cs
dc.identifier.urihttp://hdl.handle.net/11012/189392
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofInternational Journal of Molecular Sciencescs
dc.relation.urihttps://www.mdpi.com/1422-0067/21/7/2656cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1422-0067/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectcoordination compounden
dc.subjectantimicrobial compounden
dc.subjectrutheniumen
dc.subjectbenzimidazoleen
dc.subjectSEMen
dc.subjectEDSen
dc.titleA novel ruthenium based coordination compound against pathogenic bacteriaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164290en
sync.item.dbtypeVAVen
sync.item.insts2020.12.07 16:55:53en
sync.item.modts2020.12.07 16:14:18en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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