In Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth

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dc.contributor.authorMařáková, Luciecs
dc.contributor.authorPejchal, Jaroslavcs
dc.contributor.authorRoleček, Jakubcs
dc.contributor.authorVojníková, Michaelacs
dc.contributor.authorChlup, Zdeněkcs
dc.contributor.authorMařák, Vojtěchcs
dc.contributor.authorGonzález-Sánchez, Manuelacs
dc.contributor.authorČížková, Janacs
dc.contributor.authorSalamon, Davidcs
dc.coverage.issue43cs
dc.coverage.volume16cs
dc.date.accessioned2025-04-04T11:56:52Z
dc.date.available2025-04-04T11:56:52Z
dc.date.issued2024-10-21cs
dc.description.abstractHighly porous bioceramic scaffolds are widely used as bone substitutes in many applications. However, the use of bioceramics is often limited to hard tissues due to the risk of potential soft tissue calcification. A further limitation of highly porous bioceramic scaffolds is their poor mechanical stability, manifested by their tendency to break under stress. In our study, highly porous CaP-based scaffolds were prepared via freeze-casting with longitudinal and oriented pores ranging from 10 to 20 mu m and a relative porosity of similar to 70%. The resulting scaffolds achieved a flexural strength of 10.6 +/- 2.7 MPa, which, in conjunction with their favorable bioactivity, made them suitable for in vivo testing. The prepared scaffolds were subcutaneously implanted in rats for two distinct periods: 6 weeks and 6 months, respectively. The subsequent development of fibrous tissue and involvement of myofibroblasts, newly formed vessels, and macrophages were observed, with notable changes in spatial and temporal distributions within the implantation. The absence of calcification in the surrounding soft tissue, as a result of the narrow pore geometry, indicates the opportunity to tailor the scaffold behavior for soft tissue regeneration.en
dc.formattextcs
dc.format.extent58326-58336cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationACS APPL MATER INTER. 2024, vol. 16, issue 43, p. 58326-58336.en
dc.identifier.doi10.1021/acsami.4c12715cs
dc.identifier.issn1944-8244cs
dc.identifier.orcid0000-0002-2147-9917cs
dc.identifier.orcid0000-0001-7190-3985cs
dc.identifier.orcid0000-0002-3131-3064cs
dc.identifier.orcid0000-0001-6594-5214cs
dc.identifier.orcid0000-0002-3267-5235cs
dc.identifier.other191213cs
dc.identifier.researcheridB-8495-2019cs
dc.identifier.researcheridA-6219-2012cs
dc.identifier.scopus57216900419cs
dc.identifier.scopus15822747200cs
dc.identifier.urihttps://hdl.handle.net/11012/250794
dc.language.isoencs
dc.publisherAMER CHEMICAL SOCcs
dc.relation.ispartofACS APPL MATER INTERcs
dc.relation.urihttps://pubs.acs.org/doi/10.1021/acsami.4c12715cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1944-8244/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectin vivoen
dc.subjecttissue engineeringen
dc.subjectscaffoldsen
dc.subjectcalcium phosphatesen
dc.subjectfreeze-castingen
dc.subjectbioceramicsen
dc.titleIn Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowthen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-191213en
sync.item.dbtypeVAVen
sync.item.insts2025.04.04 13:56:52en
sync.item.modts2025.04.04 08:31:59en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Laserová spektroskopiecs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilá multifunkční keramikacs
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Pokročilá multifunkční keramika
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