Sarcosine as a potential prostate cancer biomarker – A review
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Date
2013-07-04
Authors
Cernei, Natalia Vladimirovna
Heger, Zbyněk
Gumulec, Jaromír
Zítka, Ondřej
Masařík, Michal
Babula, Petr
Eckschlager, Tomáš
Stiborová, Marie
Kizek, René
Adam, Vojtěch
0000-0002-8259-1566Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
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Abstract
Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there is great interest in the finding of new markers including amino acids, proteins or nucleic acids. Prostate specific antigen (PSA) is commonly used and is the most important biomarker of CaP. This marker can only be detected in blood and its sensitivity is approximately 80%. Moreover, early stages cannot be diagnosed using this protein. Currently, there does not exist a test for diagnosis of early stages of prostate cancer. This fact motivates us to find markers sensitive to the early stages of CaP, which are easily detected in body fluids including urine
Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there is great interest in the finding of new markers including amino acids, proteins or nucleic acids. Prostate specific antigen (PSA) is commonly used and is the most important biomarker of CaP. This marker can only be detected in blood and its sensitivity is approximately 80%. Moreover, early stages cannot be diagnosed using this protein. Currently, there does not exist a test for diagnosis of early stages of prostate cancer. This fact motivates us to find markers sensitive to the early stages of CaP, which are easily detected in body fluids including urine
Prostate cancer (CaP) is the most common type of tumour disease in men. Early diagnosis of cancer of the prostate is very important, because the sooner the cancer is detected, the better it is treated. According to that fact, there is great interest in the finding of new markers including amino acids, proteins or nucleic acids. Prostate specific antigen (PSA) is commonly used and is the most important biomarker of CaP. This marker can only be detected in blood and its sensitivity is approximately 80%. Moreover, early stages cannot be diagnosed using this protein. Currently, there does not exist a test for diagnosis of early stages of prostate cancer. This fact motivates us to find markers sensitive to the early stages of CaP, which are easily detected in body fluids including urine
Description
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013, vol. 14, issue 7, p. 13893-13908.
http://www.mdpi.com/1422-0067/14/7/13893
http://www.mdpi.com/1422-0067/14/7/13893
Document type
Peer-reviewed
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Published version
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Language of document
en