Biopolymeric fibers prepared by centrifugal spinning blended with ZnO nanoparticles for the treatment of Acne vulgaris

Simple item page
dc.contributor.authorŘíhová, Martinacs
dc.contributor.authorČíhalová, Kristýnacs
dc.contributor.authorPouzar, Miloslavcs
dc.contributor.authorKuthanová, Michaelacs
dc.contributor.authorJelínek, Luděkcs
dc.contributor.authorHromádko, Luděkcs
dc.contributor.authorČičmancová, Veronikacs
dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorMacák, Jancs
dc.coverage.issue1cs
dc.coverage.volume37cs
dc.date.accessioned2025-06-18T12:58:02Z
dc.date.available2025-06-18T12:58:02Z
dc.date.issued2024-04-01cs
dc.description.abstractAcne vulgaris is a serious dermatological disease affecting a significant part of the population. Currently, available therapeutics are effective only at high concentrations, which has a negative environmental and economic impact. In particular, ZnO nanoparticles (NPs) have a great potential in various biomedical applications due to their specific properties and antibacterial/antiviral activity. In this study, biomedically approved ZnO NPs with distinct diameter were used as the active therapeutic modality to treat acne-causing pathogens. For the first time, we show the utilization of ZnO NPs that were evenly distributed within centrifugally spun fiber carriers. Upon application on the skin, ZnO NPs can sustainably release and have profound antibacterial activity at lower therapeutic concentrations. Fibers were made using innovative centrifugal spinning procedure from natural polymers - gum arabic and pullulan - that are known for their biocompatibility. Different amount of ZnO NPs (from 0.03 to 4.5 wt.% related to the dry mass) was added into the spinning polymer solution, either in a form of a dry powder or as a dispersion containing NPs and isopropyl myristate. The resulting fibers were subsequently characterized for morphology and presence of ZnO NPs by Scanning Electron Microscopy and Energy-Dispersive X-ray fluorescence spectrometry. The materials were thoroughly assessed for their antibacterial activity against Cutibacterium acnes and Staphylococcus epidermidis , which are major opportunistic pathogens causing acne. The combination of two types of nanomaterials, namely active nanoparticles and fiber carriers, proved to be very promising and bear a great potential for the treatment of these diseases.en
dc.formattextcs
dc.format.extent1-7cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationApplied Materials Today. 2024, vol. 37, issue 1, p. 1-7.en
dc.identifier.doi10.1016/j.apmt.2024.102151cs
dc.identifier.issn2352-9407cs
dc.identifier.orcid0000-0002-4815-9374cs
dc.identifier.orcid0000-0002-3915-7270cs
dc.identifier.orcid0000-0001-7091-3022cs
dc.identifier.other188824cs
dc.identifier.researcheridD-1973-2013cs
dc.identifier.scopus000248159374cs
dc.identifier.scopus34872408700cs
dc.identifier.scopus55655855500cs
dc.identifier.urihttps://hdl.handle.net/11012/253583
dc.language.isoencs
dc.publisherELSEVIERcs
dc.relation.ispartofApplied Materials Todaycs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2352940724000970cs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2352-9407/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectGum arabicen
dc.subjectPullulanen
dc.subjectFibersen
dc.subjectZnOen
dc.subjectNanoparticlesen
dc.subjectAcne vulgarisen
dc.titleBiopolymeric fibers prepared by centrifugal spinning blended with ZnO nanoparticles for the treatment of Acne vulgarisen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-188824en
sync.item.dbtypeVAVen
sync.item.insts2025.06.18 14:58:02en
sync.item.modts2025.06.18 14:32:59en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé nízkodimenzionální nanomateriálycs
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1s2.0S2352940724000970main.pdf
Size:
1.63 MB
Format:
Adobe Portable Document Format
Description:
file 1s2.0S2352940724000970main.pdf
Download
Collections
Pokročilé nízkodimenzionální nanomateriály