Biogenic amines modified carbon quantum dots as antibacterial agent

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dc.contributor.authorGagić, Milicacs
dc.contributor.authorKočiová, Silviacs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorŠmerková, Kristýnacs
dc.contributor.authorMilosavljević, Vedrancs
dc.date.issued2019-12-31cs
dc.description.abstractAn alternative to conventional way is needed to treat multiple drug resistant bacteria. In this work, four different amine modified carbon quantum dots (CQDs) were obtained by microwave irradiation treatment. The four different biogenic amines (spermidine, putrescine, cadaverine, and histamine) as capping agent and citric acid as a carbon precursor were used. Prepared CQDs were evaluated for their antibacterial activity against three common pathogenic bacteria (Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus), and the growth curves were modeled. The CQDs showed a strong broad-spectrum antibacterial activity. The bactericidal activity was linked to their specific surface chemistry and caused bacterial death, which was due to the electrostatic interactions between protonated CQDs and the lipids of the bacterial cell membrane. The biocompatibility of CQDs was tested in HBL100 and HEK293 cell lines and low or absence of toxicity was indicated.en
dc.formattextcs
dc.format.extent569-573cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMendelNet 2019 Proceedings of 26th International PhD Students Conference. 2019, p. 569-573.en
dc.identifier.isbn978-80-7509-688-3cs
dc.identifier.orcid0000-0002-6851-6332cs
dc.identifier.orcid0000-0002-8288-3999cs
dc.identifier.orcid0000-0002-1667-7660cs
dc.identifier.orcid0000-0003-4122-0694cs
dc.identifier.other161383cs
dc.identifier.researcheridN-9991-2014cs
dc.identifier.researcheridP-3551-2018cs
dc.identifier.scopus12040049600cs
dc.identifier.scopus56115133500cs
dc.identifier.urihttp://hdl.handle.net/11012/184640
dc.language.isoencs
dc.publisherMendel University in Brnocs
dc.relation.ispartofMendelNet 2019 Proceedings of 26th International PhD Students Conferencecs
dc.relation.urihttps://mendelnet.cz/artkey/mnt-201901-0108_Biogenic-amines-modified-carbon-quantum-dots-as-antibacterial-agent.php?back=/magno/mnt/2019/mn1.php?secid=4cs
dc.rights(C) Mendel University in Brnocs
dc.rights.accessopenAccesscs
dc.subjectcarbon quantum dotsen
dc.subjectantibacterialen
dc.subjectbiogenic aminesen
dc.subjectpathogenic bacteriaen
dc.subjectresistanceen
dc.titleBiogenic amines modified carbon quantum dots as antibacterial agenten
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-161383en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:49:55en
sync.item.modts2025.01.17 15:17:07en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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