Differences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumors

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dc.contributor.authorDušková, Kateřinacs
dc.contributor.authorVeselý, Štěpáncs
dc.contributor.authorDo Carmo Silva, Joana Isabelcs
dc.contributor.authorCernei, Natalia Vladimirovnacs
dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHavlová, Kláracs
dc.contributor.authorBabjuk, Marekcs
dc.coverage.issue2cs
dc.coverage.volume32cs
dc.date.accessioned2020-08-04T11:04:13Z
dc.date.available2020-08-04T11:04:13Z
dc.date.issued2018-04-01cs
dc.description.abstractBackground: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. Materials and Methods: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n = 30), urinary bladder cancer (n = 28), renal cell carcinoma (n = 16) and healthy volunteers (control group; n = 21). Results: In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma. Conclusion: Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors.en
dc.formattextcs
dc.format.extent425-429cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationIN VIVO. 2018, vol. 32, issue 2, p. 425-429.en
dc.identifier.doi10.21873/invivo.11257cs
dc.identifier.issn0258-851Xcs
dc.identifier.other147613cs
dc.identifier.urihttp://hdl.handle.net/11012/80179
dc.language.isoencs
dc.publisherThe International Institute of Anticancer Researchcs
dc.relation.ispartofIN VIVOcs
dc.relation.urihttp://iv.iiarjournals.org/content/32/2/425.abstractcs
dc.rights(C) The International Institute of Anticancer Researchcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0258-851X/cs
dc.subjectAmino acidsen
dc.subjectprostate canceren
dc.subjectrenal cell carcinomaen
dc.subjecturinary bladder canceren
dc.titleDifferences in Urinary Amino Acid Patterns in Individuals with Different Types of Urological Tumor Urinary Amino Acid Patterns as Markers of Urological Tumorsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-147613en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:04:13en
sync.item.modts2020.08.04 12:44:02en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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