The Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cells

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dc.contributor.authorŠtěpánková, Hanacs
dc.contributor.authorSwiatkowski, Marcincs
dc.contributor.authorKruszyński, Rafałcs
dc.contributor.authorŠvec, Pavelcs
dc.contributor.authorMichálková, Hanacs
dc.contributor.authorSmolíková, Vendulacs
dc.contributor.authorRidošková, Andreacs
dc.contributor.authorŠplíchal, Zbyněkcs
dc.contributor.authorMichálek, Petrcs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorRex, Simonacs
dc.coverage.issue1cs
dc.coverage.volume16cs
dc.date.accessioned2021-08-12T10:53:22Z
dc.date.available2021-08-12T10:53:22Z
dc.date.issued2021-07-12cs
dc.description.abstractPurpose: The present study deals with the in vitro evaluation of the potential use of coordination compound-based zinc oxide (ZnO) nanoparticles (NPs) for the treatment of triple negative breast cancer cells (TNBrCa). As BrCa is one of the most prevalent cancer types and TNBrCa treatment is difficult due to poor prognosis and a high metastasis rate, finding a more reliable treatment option should be of the utmost interest. Methods: Prepared by reacting zinc carboxylates (formate, acetate, propionate, butyrate, isobutyrate, valerate) and hexamethylenetetramine, 4 distinct coordination compounds were further subjected to two modes of conversion into ZnO NPs - ultrasonication with oleic acid or heating of pure precursors in an air atmosphere. After detailed characterization, the resulting ZnO NPs were subjected to in vitro testing of cytotoxicity toward TNBrCa and normal breast epithelial cells. Further, their biocompatibility was evaluated. Results: The resulting ZnO NPs provide distinct morphological features, size, biocompatibility, and selective cytotoxicity toward TNBrCa cells. They internalize into two types of TNBrCa cells and imbalance their redox homeostasis, influencing their metabolism, morphology, and ultimately leading to their death via apoptosis or necrosis. Conclusion: The crucial properties of ZnO NPs seem to be their morphology, size, and zinc content. The ZnO NPs with the most preferential values of all three properties show great promise for a future potential use in the therapy of TNBrCa.en
dc.formattextcs
dc.format.extent4431-4449cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Nanomedicine. 2021, vol. 16, issue 1, p. 4431-4449.en
dc.identifier.doi10.2147/IJN.S304902cs
dc.identifier.issn1178-2013cs
dc.identifier.other171965cs
dc.identifier.urihttp://hdl.handle.net/11012/200950
dc.language.isoencs
dc.publisherDove Presscs
dc.relation"European Union (EU)" & "Horizon 2020"
dc.relation.ispartofInternational Journal of Nanomedicinecs
dc.relation.projectIdinfo:eu-repo/grantAgreement/EC/H2020/759585/EU//ToMeTuM
dc.relation.urihttps://www.dovepress.com/the-anti-proliferative-activity-of-coordination-compound-based-zno-nan-peer-reviewed-fulltext-article-IJNcs
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1178-2013/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/cs
dc.subjectcarboxylateen
dc.subjecthexamethylenetetramineen
dc.subjectnanoparticlesen
dc.subjectredox homeostasis imbalanceen
dc.subjecttriple negative breast canceren
dc.subjectzinc oxide coordination compoundsen
dc.titleThe Anti-Proliferative Activity of Coordination Compound-Based ZnO Nanoparticles as a Promising Agent Against Triple Negative Breast Cancer Cellsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-171965en
sync.item.dbtypeVAVen
sync.item.insts2021.11.20 00:53:05en
sync.item.modts2021.11.20 00:16:30en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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