Assessing Earthworm Exposure to a Multi-Pharmaceutical Mixture in Soil: Unveiling Insights through LC-MS and MALDI-MS Analyses, and Impact of Biochar on Pharmaceutical Bioavailability

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dc.contributor.authorFučík, Jancs
dc.contributor.authorJarošová, Janacs
dc.contributor.authorBaumeister, Andreascs
dc.contributor.authorRexroth, Saschacs
dc.contributor.authorNavrkalová, Jitkacs
dc.contributor.authorSedlář, Mariancs
dc.contributor.authorZlámalová Gargošová, Helenacs
dc.contributor.authorMravcová, Ludmilacs
dc.coverage.issue35cs
dc.coverage.volume31cs
dc.date.accessioned2025-02-28T13:53:49Z
dc.date.available2025-02-28T13:53:49Z
dc.date.issued2024-07-19cs
dc.description.abstractIn the European circular economy, agricultural practices introduce pharmaceutical (PhAC) residues into the terrestrial environment, posing a potential risk to earthworms. This study aimed to assess earthworm bioaccumulation factors (BAFs), the ecotoxicological effects of PhACs, the impact of biochar on PhAC bioavailability to earthworms and their persistence in soil and investigate earthworm uptake mechanisms along with the spatial distribution of PhACs. Therefore, earthworms were exposed to contaminated soil for 21 days. The results revealed that BAFs ranged from 0.0216 to 0.329, with no significant ecotoxicological effects on earthworm weight or mortality (p>0.05). Biochar significantly influenced the uptake of 14 PhACs on the first day (p<0.05), with diminishing effects over time, and affected significantly the soil-degradation kinetics of 16 PhACs. Moreover, MALDI-MS analysis revealed that PhAC uptake occurs through both the dermal and oral pathways, as pharmaceuticals were distributed throughout the entire earthworm tissue without specific localization. In conclusion, this study suggests ineffective PhAC accumulation in earthworms, highlights the influence of biochar on PhAC degradation rates in soil, and suggests that uptake can occur through both earthworm skin and oral ingestion.en
dc.formattextcs
dc.format.extent48351-58368cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. 2024, vol. 31, issue 35, p. 48351-58368.en
dc.identifier.doi10.1007/s11356-024-34389-1cs
dc.identifier.issn0944-1344cs
dc.identifier.orcid0000-0002-3408-4383cs
dc.identifier.orcid0000-0003-4536-3983cs
dc.identifier.orcid0000-0001-8309-8012cs
dc.identifier.orcid0000-0003-1011-6616cs
dc.identifier.other189012cs
dc.identifier.researcheridG-9690-2018cs
dc.identifier.scopus25621742800cs
dc.identifier.urihttps://hdl.handle.net/11012/250075
dc.language.isoencs
dc.publisherSpringer-Verlagcs
dc.relation.ispartofENVIRONMENTAL SCIENCE AND POLLUTION RESEARCHcs
dc.relation.urihttps://link.springer.com/article/10.1007/s11356-024-34389-1cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/0944-1344/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectPharmaceutical uptake; soil pollution; earthworms; biochar; QuEChERSen
dc.subjectliquid chromatographyen
dc.subjectmass spectrometryen
dc.subjectMALDI-MSen
dc.titleAssessing Earthworm Exposure to a Multi-Pharmaceutical Mixture in Soil: Unveiling Insights through LC-MS and MALDI-MS Analyses, and Impact of Biochar on Pharmaceutical Bioavailabilityen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189012en
sync.item.dbtypeVAVen
sync.item.insts2025.02.28 14:53:49en
sync.item.modts2025.02.28 13:32:01en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie a technologie ochrany životního prostředícs
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé biomateriálycs
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