Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

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dc.contributor.authorVilla, Katherinecs
dc.contributor.authorViktorová, Jitkacs
dc.contributor.authorPlutnar, Jancs
dc.contributor.authorRuml, Tomášcs
dc.contributor.authorHoang, Lancs
dc.contributor.authorPumera, Martincs
dc.coverage.issue9cs
dc.coverage.volume1cs
dc.date.accessioned2021-01-14T11:54:10Z
dc.date.available2021-01-14T11:54:10Z
dc.date.issued2020-09-23cs
dc.description.abstractMouths offer the perfect environments for microbial cell formation, promoting the growth of biofilms, for example, on teeth. Dental biofilm exhibits strong resistance to antibiotics and is a cause of many dental diseases. Common strategies for dental biofilm removal involve the addition of high concentrations of hydrogen peroxide (H2O2), which increases tooth sensitivity, or mechanical procedures. Here, we report a different approach based on self-propelled micromachines with high antibacterial activity for the degradation of dental biofilm. Such microrobots use low concentrations of fuel for their propulsion, and they achieve an efficient dental biofilm disruption in only 5 min of treatment. Moreover, these microrobots are biocompatible with epidermal and organ cells and may stimulate the immune system to fight against microbial infection. This approach of exploiting the active motion of bubble-propelled catalytic micromachines for oral biofilm disruption may open the door for more efficient and sophisticated treatments in dentistry.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationCell Reports Physical Science. 2020, vol. 1, issue 9, p. 1-18.en
dc.identifier.doi10.1016/j.xcrp.2020.100181cs
dc.identifier.issn2666-3864cs
dc.identifier.other167681cs
dc.identifier.urihttp://hdl.handle.net/11012/195857
dc.language.isoencs
dc.publisherCell Presscs
dc.relation.ispartofCell Reports Physical Sciencecs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S2666386420301922cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2666-3864/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectmicromotorsen
dc.subjectbubble propulsionen
dc.subjecthydroxyl radicalsen
dc.subjectdental biofilmen
dc.subjecttitanium dioxideen
dc.subjectantibacterial activityen
dc.subjectbiofilm disruptionen
dc.subjectgum treatmenten
dc.titleChemical Microrobots as Self-Propelled Microbrushes against Dental Biofilmen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-167681en
sync.item.dbtypeVAVen
sync.item.insts2021.12.07 16:54:08en
sync.item.modts2021.12.07 16:14:33en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
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