Toward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsy

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dc.contributor.authorStrýček, Ondřejcs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorMiklánek, Štěpáncs
dc.contributor.authorFusek, Michalcs
dc.contributor.authorŠtillová, Kláracs
dc.contributor.authorMazánek, Martincs
dc.contributor.authorRektor, Ivancs
dc.coverage.issue7cs
dc.coverage.volume32cs
dc.date.accessioned2025-07-16T13:56:10Z
dc.date.available2025-07-16T13:56:10Z
dc.date.issued2025-07-05cs
dc.description.abstractBackground Music-based neuromodulation has garnered interest as a potential therapeutic approach for drug-resistant epilepsy. This study expands on prior research by examining the effects of different musical features on interictal epileptiform discharges (IEDs) within intracerebral EEG (iEEG). Methods Twenty-five patients with drug-resistant epilepsy undergoing presurgical iEEG evaluation participated in the study. Over 2days, patients listened to various musical compositions characterized by distinct acoustic properties. EEG measurements were recorded before and after each listening session to evaluate IED changes. Results The study identified individualized patterns in IED reduction, with certain acoustic properties showing consistent effects across musical genres. Mozart's “Piano Concerto No. 27” K 595c globally reduced IEDs by 28% while listening to music (p=0.0191) and 19% in the postmusic resting state (p=0.0111); relaxation music increased IEDs by 55% (p=0.0197). Based on the acoustic analysis of individuals, we identified compositions that significantly reduced IEDs, with reductions ranging from 32% to 44% (p=0.0001). In contrast, compositions with differing acoustic properties did not result in significant changes in IEDs. These results suggest that specific acoustic properties, rather than genre, primarily influence IEDs. Conclusions The findings suggest that specific acoustic properties can influence brain activity in a reproducible manner at the individual level, modulating IEDs based on personalized testing and selection across a spectrum of musical genres. These results suggest the potential for music-based neuromodulation as a personalized therapeutic approach in epilepsy management, emphasizing the importance of acoustic features over musical genre. Further research is needed to explore individual aspects of music-based interventions.en
dc.formattextcs
dc.format.extent1-9cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationEuropean Journal of Neurology. 2025, vol. 32, issue 7, p. 1-9.en
dc.identifier.doi10.1111/ene.70151cs
dc.identifier.issn1351-5101cs
dc.identifier.orcid0000-0002-6195-193Xcs
dc.identifier.orcid0000-0002-4561-4677cs
dc.identifier.orcid0000-0002-9842-8384cs
dc.identifier.other198293cs
dc.identifier.researcheridK-4001-2015cs
dc.identifier.researcheridE-4920-2018cs
dc.identifier.scopus35746344400cs
dc.identifier.scopus39161155400cs
dc.identifier.urihttps://hdl.handle.net/11012/255164
dc.language.isoencs
dc.publisherWileycs
dc.relation.ispartofEuropean Journal of Neurologycs
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1111/ene.70151cs
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1351-5101/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/cs
dc.subjectacoustic propertiesen
dc.subjectepilepsyen
dc.subjectiEEGen
dc.subjectinterictal epileptiform dischargesen
dc.subjectmusicen
dc.titleToward a Tailored Acoustic-Based Approach in Music Neuromodulation in Epilepsyen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-198293en
sync.item.dbtypeVAVen
sync.item.insts2025.07.16 15:56:10en
sync.item.modts2025.07.16 14:32:54en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav matematikycs
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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