Articulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measures

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dc.contributor.authorKlobušiaková, Patríciacs
dc.contributor.authorMekyska, Jiřícs
dc.contributor.authorBrabenec, Lubošcs
dc.contributor.authorGaláž, Zoltáncs
dc.contributor.authorZvončák, Vojtěchcs
dc.contributor.authorMucha, Jáncs
dc.contributor.authorRapcsak, Steven Z.cs
dc.contributor.authorRektorová, Irenacs
dc.coverage.issue1cs
dc.coverage.volume84cs
dc.date.accessioned2021-12-14T15:55:53Z
dc.date.available2021-12-14T15:55:53Z
dc.date.issued2021-03-01cs
dc.description.abstractIntroduction: Hypokinetic dysarthria (HD) is common in Parkinson's disease (PD). Our objective was to evaluate articulatory networks and their reorganization due to PD pathology in individuals without overt speech impairment using a multimodal MRI protocol and acoustic analysis of speech. Methods: A total of 34 PD patients with no subjective HD complaints and 25 age-matched healthy controls (HC) underwent speech task recordings, structural MRI, and reading task-induced and resting-state fMRI. Grey matter probability maps, task-induced activations, and resting-state functional connectivity within the regions engaged in speech production (ROIs) were assessed and compared between groups. Correlation with acoustic parameters was also performed. Results: PD patients as compared Tto HC displayed temporal decreases in speech loudness which were related to BOLD signal increases in the right-sided regions of the dorsal language pathway/articulatory network. Among those regions, activation of the right anterior cingulate was increased in PD as compared to HC. We also found bilateral posterior superior temporal gyrus (STG) GM loss in PD as compared to HC that was strongly associated with diadochokinetic (DDK) irregularity in the PD group. Task-induced activations of the left STG were increased in PD as compared to HC and were related to the DDK rate control. Conclusions: The results provide insight into the neural correlates of speech production control and distinct articulatory network reorganization in PD apparent already in patients without subjective speech impairment.en
dc.formattextcs
dc.format.extent122-128cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPARKINSONISM & RELATED DISORDERS. 2021, vol. 84, issue 1, p. 122-128.en
dc.identifier.doi10.1016/j.parkreldis.2021.02.012cs
dc.identifier.issn1353-8020cs
dc.identifier.other169834cs
dc.identifier.urihttp://hdl.handle.net/11012/203211
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofPARKINSONISM & RELATED DISORDERScs
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1353802021000535cs
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1353-8020/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/cs
dc.subjectacoustic analysisen
dc.subjecthypokinetic dysarthriaen
dc.subjectfMRIen
dc.subjectParkinson's diseaseen
dc.subjectvoxel-based morphometryen
dc.subjectresting-state functional connectivityen
dc.titleArticulatory network reorganization in Parkinson's disease as assessed by multimodal MRI and acoustic measuresen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-169834en
sync.item.dbtypeVAVen
sync.item.insts2021.12.14 16:55:53en
sync.item.modts2021.12.14 16:15:21en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav telekomunikacícs
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