Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels

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dc.contributor.authorHeger, Richardcs
dc.contributor.authorZinkovska, Nataliacs
dc.contributor.authorTrudičová, Monikacs
dc.contributor.authorKadlec, Martincs
dc.contributor.authorPekař, Miloslavcs
dc.contributor.authorSmilek, Jiřícs
dc.coverage.issue5cs
dc.coverage.volume9cs
dc.date.issued2023-04-27cs
dc.description.abstractTransport properties are one of the most crucial assets of hydrogel samples, influencing their main application potential, i.e., as drug carriers. Depending on the type of drug or the application itself, it is very important to be able to control these transport properties in an appropriate manner. This study seeks to modify these properties by adding amphiphiles, specifically lecithin. Through its self-assembly, lecithin modifies the inner structure of the hydrogel, which affects its properties, especially the transport ones. In the proposed paper, these properties are studied mainly using various probes (organic dyes) to effectively simulate drugs in simple release diffusion experiments controlled by UV-Vis spectrophotometry. Scanning electron microscopy was used to help characterize the diffusion systems. The effects of lecithin and its concentrations, as well as the effects of variously charged model drugs, were discussed. Lecithin decreases the values of the diffusion coefficient independently of the dye used and the type of crosslinking. The ability to influence transport properties is better observed in xerogel samples. The results, complementing previously published conclusions, showed that lecithin can alter a hydrogel’s structure and therefore its transport properties.en
dc.formattextcs
dc.format.extent18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationGels. 2023, vol. 9, issue 5, 18 p.en
dc.identifier.doi10.3390/gels9050367cs
dc.identifier.issn2310-2861cs
dc.identifier.orcid0000-0002-4844-2954cs
dc.identifier.orcid0000-0001-7268-5641cs
dc.identifier.orcid0000-0002-3878-0917cs
dc.identifier.orcid0000-0002-6553-1764cs
dc.identifier.other184017cs
dc.identifier.scopus57207823371cs
dc.identifier.scopus55844628200cs
dc.identifier.urihttp://hdl.handle.net/11012/213544
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofGelscs
dc.relation.urihttps://www.mdpi.com/2310-2861/9/5/367cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2310-2861/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectdiffusionen
dc.subjectextracellular matrixen
dc.subjecthydrogelen
dc.subjectlecithinen
dc.subjectmodel drugsen
dc.subjectscanning electron microscopyen
dc.subjecttransport propertiesen
dc.titleLecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogelsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-184017en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:56en
sync.item.modts2025.01.17 15:22:56en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav fyzikální a spotřební chemiecs
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