Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels
Loading...
Date
2023-04-27
Authors
Heger, Richard
Zinkovska, Natalia
Trudičová, Monika
Kadlec, Martin
Pekař, Miloslav
Smilek, Jiří
0000-0002-4844-2954Advisor
Referee
Mark
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Altmetrics
Abstract
Transport properties are one of the most crucial assets of hydrogel samples, influencing their main application potential, i.e., as drug carriers. Depending on the type of drug or the application itself, it is very important to be able to control these transport properties in an appropriate manner. This study seeks to modify these properties by adding amphiphiles, specifically lecithin. Through its self-assembly, lecithin modifies the inner structure of the hydrogel, which affects its properties, especially the transport ones. In the proposed paper, these properties are studied mainly using various probes (organic dyes) to effectively simulate drugs in simple release diffusion experiments controlled by UV-Vis spectrophotometry. Scanning electron microscopy was used to help characterize the diffusion systems. The effects of lecithin and its concentrations, as well as the effects of variously charged model drugs, were discussed. Lecithin decreases the values of the diffusion coefficient independently of the dye used and the type of crosslinking. The ability to influence transport properties is better observed in xerogel samples. The results, complementing previously published conclusions, showed that lecithin can alter a hydrogel’s structure and therefore its transport properties.
Description
Citation
Document type
Peer-reviewed
Document version
Published version
Date of access to the full text
Language of document
en