Distance-based paper microfluidic devices for rapid visual quantification of heavy metals in herbal supplements and cosmetics

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dc.contributor.authorManmana, Yanawutcs
dc.contributor.authorMacka, Miroslavcs
dc.contributor.authorNuchtavorn, Nantanacs
dc.coverage.issue49cs
dc.coverage.volume14cs
dc.date.issued2024-11-11cs
dc.description.abstractDistance-based detection (DbD) on paper-based microfluidic analytical devices (mu PADs) has emerged as a promising, cost-effective, simple, and instrumentation-free assay method. Broadening the applicability of a new way of immobilization of reagent for DbD on mu PADs (D mu PADs) is presented, employing an ion exchange (IE) interaction of an anionic metallochromic reagent, 2-(5-bromo-2-pyridylazo)-5-[N-n-propyl-N-(3-sulfopropyl)amino]phenol (5-Br-PAPS), on the anion-exchange filter paper. The IE D mu PADs demonstrate superiority over standard cellulose filter paper in terms of the degree of reagent immobilization, detection sensitivity, and clear detection endpoints due to the strong retention of 5-Br-PAPS. The study investigated various parameters influencing DbD, including 5-Br-PAPS concentrations (0.25-1 mM), buffer types (acetic acid-Tris, MES), buffer concentrations (20-500 mM), and auxiliary complexing agents (acetic, formic, and glycolic acids). Subsequently, the performance of 17 metals (Ag+, Cd2+, Co2+, Cr3+, Cu2+, Fe2+, Hg2+, La2+, Mn2+, Ni2+, Pb2+, Ti2+, Zn2+, Al3+, As3+, Fe3+, and V4+) was evaluated, with color formation observed for 12 metals. Additionally, the paper surface was examined using SEM and SEM-EDX to verify the suitability of certain areas in the detection channel for reagent immobilization and metal binding. This method demonstrates quantitation limits of metals in the low mu g mL-1 range, showing great potential for the rapid screening of toxic metals commonly found in herbal supplements and cosmetics regulated by the Food and Drug Administration (FDA). Thus, it holds promise for enhancing safety and regulatory compliance in product quality assessment. Furthermore, this method offers a cost-effective, environmentally sustainable, and user-friendly approach for the rapid visual quantification of heavy metals for in-field analysis, eliminating the need for complex instrumentation.en
dc.formattextcs
dc.format.extent36142-36151cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationRSC Advances. 2024, vol. 14, issue 49, p. 36142-36151.en
dc.identifier.doi10.1039/d4ra05358ccs
dc.identifier.issn2046-2069cs
dc.identifier.orcid0000-0002-6792-2574cs
dc.identifier.other197229cs
dc.identifier.researcheridG-6553-2012cs
dc.identifier.scopus7004295072cs
dc.identifier.urihttp://hdl.handle.net/11012/250851
dc.language.isoencs
dc.publisherRoyal Society of Chemistrycs
dc.relation.ispartofRSC Advancescs
dc.relation.urihttps://pubs.rsc.org/en/content/articlelanding/2024/ra/d4ra05358ccs
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2046-2069/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/cs
dc.subjectSEPARATIONen
dc.subjectSURFACEen
dc.subjectIONSen
dc.titleDistance-based paper microfluidic devices for rapid visual quantification of heavy metals in herbal supplements and cosmeticsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-197229en
sync.item.dbtypeVAVen
sync.item.insts2025.05.26 09:56:44en
sync.item.modts2025.05.26 09:32:59en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Laserová spektroskopiecs
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