Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal

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dc.contributor.authorUssia, Martinacs
dc.contributor.authorUrso, Mariocs
dc.contributor.authorKment, Štěpáncs
dc.contributor.authorFialová, Tatianacs
dc.contributor.authorKlíma, Karelcs
dc.contributor.authorČíhalová, Kristýnacs
dc.contributor.authorPumera, Martincs
dc.coverage.issue22cs
dc.coverage.volume18cs
dc.date.accessioned2022-10-07T10:53:21Z
dc.date.available2022-10-07T10:53:21Z
dc.date.issued2022-06-01cs
dc.description.abstractTitanium miniplates are biocompatible materials used in modern oral and maxillofacial surgery to treat facial bone fractures. However, plate removal is often required due to implant complications. Among them, a biofilm formation on an infected miniplate is associated with severe inflammation, which frequently results in implant failure. In light of this, new strategies to control or treat oral bacterial biofilm are of high interest. Herein, the authors exploit the ability of nanorobots against multispecies bacterial biofilm grown onto facial commercial titanium miniplate implants to simulate pathogenic conditions of the oral microenvironment. The strategy is based on the use of light-driven self-propelled tubular black-TiO2/Ag nanorobots, that unlike traditional ones, exhibit an extended absorption and motion actuation from UV to the visible-light range. The motion analysis is performed separately over UV, blue, and green light irradiation and shows different motion behaviors, including a fast rotational motion that decreases with increasing wavelengths. The biomass reduction is monitored by evaluating LIVE/DEAD fluorescent and digital microscope images of bacterial biofilm treated with the nanorobots under motion/no-motion conditions. The current study and the obtained results can bring significant improvements for effective therapy of infected metallic miniplates by biofilm.en
dc.description.embargo2023-06-02cs
dc.formattextcs
dc.format.extent1-10cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationSmall. 2022, vol. 18, issue 22, p. 1-10.en
dc.identifier.doi10.1002/smll.202200708cs
dc.identifier.issn1613-6829cs
dc.identifier.other178690cs
dc.identifier.urihttp://hdl.handle.net/11012/208469
dc.language.isoencs
dc.publisherWiley VCHcs
dc.relation.ispartofSmallcs
dc.relation.urihttps://onlinelibrary.wiley.com/doi/10.1002/smll.202200708cs
dc.rights(C) Wiley VCHcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1613-6829/cs
dc.subjectbacteriaen
dc.subjectblack TiOen
dc.subject(2)en
dc.subjectdental implantsen
dc.subjectnanomotorsen
dc.subjectsilveren
dc.subjectUV lighten
dc.subjectvisible lighten
dc.titleLight-Propelled Nanorobots for Facial Titanium Implants Biofilms Removalen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionacceptedVersionen
sync.item.dbidVAV-178690en
sync.item.dbtypeVAVen
sync.item.insts2023.06.03 00:53:02en
sync.item.modts2023.06.03 00:14:38en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Energie budoucnosti a inovacecs
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