Novel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureus

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dc.contributor.authorJelínková, Pavlínacs
dc.contributor.authorŠplíchal, Zbyněkcs
dc.contributor.authorJimenez Jimenez, Ana Mariacs
dc.contributor.authorHaddad, Yazan Abdulmajeed Eyadhcs
dc.contributor.authorMazumdar, Anindacs
dc.contributor.authorSur, Vishma Pratapcs
dc.contributor.authorMilosavljević, Vedrancs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorBuchtelová, Hanacs
dc.contributor.authorGuráň, Romancs
dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorHegerová, Dagmarcs
dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorMoulick, Amitavacs
dc.contributor.authorAdam, Vojtěchcs
dc.coverage.issue1cs
dc.coverage.volume11cs
dc.date.accessioned2020-08-04T11:03:39Z
dc.date.available2020-08-04T11:03:39Z
dc.date.issued2018-11-01cs
dc.description.abstractBackground: Increase in vancomycin (Van)-resistant bacterial strains including vancomycin-resistant Staphylococcus aureus (VRSA) and lack of new effective antibiotics have become a formidable health problem. Materials and methods: We designed a new conjugate composed of Van and a peptide Hecate (Hec; Van/Hec), and its potential antimicrobial activity was evaluated. Results: Results from disk diffusion test, time-kill assay, determination of minimum inhibitory concentration (MIC), microscopy, and comet assay showed strong antimicrobial effects of Van/Hec against wild-type, methicillin-resistant Staphylococcus aureus (MRSA) and VRSA. Microscopy revealed that the exposure to Van/Hec results in disruption of bacterial cell integrity in all tested strains, which was not observed in case of Van or Hec alone. Conclusion: Overall, we showed that the preparation of conjugates from antibiotics and biologically active peptides could help us to overcome the limitation of the use of antibiotic in the treatment of infections caused by multidrug-resistant bacteria.en
dc.formattextcs
dc.format.extent1807-1817cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInfection and Drug Resistance. 2018, vol. 11, issue 1, p. 1807-1817.en
dc.identifier.doi10.2147/IDR.S160975cs
dc.identifier.issn1178-6973cs
dc.identifier.other151171cs
dc.identifier.urihttp://hdl.handle.net/11012/137077
dc.language.isoencs
dc.publisherDove Presscs
dc.relation.ispartofInfection and Drug Resistancecs
dc.relation.urihttps://www.dovepress.com/novel-vancomycinndashpeptide-conjugate-as-potent-antibacterial-agent-a-peer-reviewed-article-IDRcs
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1178-6973/cs
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/cs
dc.subjectVancomycinen
dc.subjectantibacterialen
dc.subjectStaphylococcus aureusen
dc.subjectantibiotic resistanceen
dc.subjectpeptideen
dc.titleNovel Vancomycin-Peptide Conjugate as Potent Antibacterial Agent against Vancomycin-Resistant Staphylococcus aureusen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-151171en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:03:39en
sync.item.modts2020.08.04 12:33:50en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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