Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences

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dc.contributor.authorBohálová, Natáliacs
dc.contributor.authorCantara, Alessiocs
dc.contributor.authorBartas, Martincs
dc.contributor.authorKaura, Patrikcs
dc.contributor.authorŠťastný, Jiřícs
dc.contributor.authorPečinka, Petrcs
dc.contributor.authorFojta, Miroslavcs
dc.contributor.authorBrázda, Václavcs
dc.coverage.issue7cs
dc.coverage.volume22cs
dc.date.accessioned2021-07-23T10:53:08Z
dc.date.available2021-07-23T10:53:08Z
dc.date.issued2021-04-01cs
dc.description.abstractThe importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all reference viral dsDNA genomes and evaluate their dependence on PQS occurrence in host organisms using the G4Hunter tool. PQS frequencies differ across host taxa without regard to GC content. The overlay of PQS with annotated regions reveals the localization of PQS in specific regions. While abundance in some, such as repeat regions, is shared by all groups, others are unique. There is abundance within introns of Eukaryota-infecting viruses, but depletion of PQS in introns of bacteria-infecting viruses. We reveal a significant positive correlation between PQS frequencies in dsDNA viruses and corresponding hosts from archaea, bacteria, and eukaryotes. A strong relationship between PQS in a virus and its host indicates their close coevolution and evolutionarily reciprocal mimicking of genome organization.en
dc.formattextcs
dc.format.extent1-12cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Molecular Sciences. 2021, vol. 22, issue 7, p. 1-12.en
dc.identifier.doi10.3390/ijms22073433cs
dc.identifier.issn1422-0067cs
dc.identifier.other171724cs
dc.identifier.urihttp://hdl.handle.net/11012/200878
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofInternational Journal of Molecular Sciencescs
dc.relation.urihttps://www.mdpi.com/1422-0067/22/7/3433cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1422-0067/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectBioinformaticsen
dc.subjectCoevolutionen
dc.subjectDsDNAen
dc.subjectG-quadruplexen
dc.subjectG4Hunteren
dc.subjectHosten
dc.subjectVirusen
dc.titleTracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequencesen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-171724en
sync.item.dbtypeVAVen
sync.item.insts2021.08.30 23:53:59en
sync.item.modts2021.08.30 22:49:28en
thesis.grantorVysoké učení technické v Brně. Fakulta strojního inženýrství. Ústav automatizace a informatikycs
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