Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53

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dc.contributor.authorKoudelková, Zuzanacs
dc.contributor.authorSedláčková, Eliškacs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorŠvec, Pavelcs
dc.contributor.authorAdam, Vojtěchcs
dc.date.accessioned2021-05-04T10:54:19Z
dc.date.available2021-05-04T10:54:19Z
dc.date.issued2020-06-10cs
dc.description.abstractCancer is one of the most common causes of death in developing countries and in the developed world. The function of the p53 protein plays an important role in the development of cancer. The protein p53 regulates the expression of genes that are responsible for the control of cell growth, apoptosis or for repair of damaged DNA. It t is encoded by the tumor suppressor gene TP53. If this gene mutates, its product will be damaged. It was found that mutations in the TP53 gene is present in more than 50% of cancer cases. Electrochemical biosensors have proved to be a suitable method for the detection of TP53 and also its mutations. Electrochemical deposition of gold nanoparticles on the surface of working electrode increases the active surface area of the sensor, this leads to a more sensitive detection of the TP53 gene and its mutations. By developing an electrochemical biosensor based on gold nanoparticles modified screen printed electrodes, an efficient platform for detecting the TP53 gene in biological samples is obtained.en
dc.formattextcs
dc.format.extent402-405cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationNANOCON 2019 CONFERENCE PROCEEDINGS. 2020, p. 402-405.en
dc.identifier.doi10.37904/nanocon.2019.8611cs
dc.identifier.isbn978-80-87294-95-6cs
dc.identifier.other164268cs
dc.identifier.urihttp://hdl.handle.net/11012/196674
dc.language.isoencs
dc.publisherTangercs
dc.relation.ispartofNANOCON 2019 CONFERENCE PROCEEDINGScs
dc.relation.urihttps://doi.org/10.37904/nanocon.2019.8611cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectScreen printed electrodeen
dc.subjectgold nanoparticlesen
dc.subjectgene TP53en
dc.subjectprotein p53en
dc.subjectelectrochemistryen
dc.titleGold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53en
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-164268en
sync.item.dbtypeVAVen
sync.item.insts2021.05.04 12:54:19en
sync.item.modts2021.05.04 12:14:47en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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