Exposure to 17 beta-Oestradiol Induces Oxidative Stress in the Non-Oestrogen Receptor Invertebrate Species Eisenia fetida

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dc.contributor.authorHeger, Zbyněkcs
dc.contributor.authorMichálek, Petrcs
dc.contributor.authorGuráň, Romancs
dc.contributor.authorHavelková, Barboracs
dc.contributor.authorKomínková, Markétacs
dc.contributor.authorCernei, Natalia Vladimirovnacs
dc.contributor.authorRichtera, Lukášcs
dc.contributor.authorBeklová, Miroslavacs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorKizek, Renécs
dc.coverage.issue12cs
dc.coverage.volume10cs
dc.date.accessioned2020-08-04T11:03:59Z
dc.date.available2020-08-04T11:03:59Z
dc.date.issued2015-12-22cs
dc.description.abstractBackground The environmental impacts of various substances on all levels of organisms are under investigation. Among these substances, endocrine-disrupting compounds (EDCs) present a threat, although the environmental significance of these compounds remains largely unknown. To shed some light on this field, we assessed the effects of 17 beta-oestradiol on the growth, reproduction and formation of free radicals in Eisenia fetida. Methodology/Principal Findings Although the observed effects on growth and survival were relatively weak, a strong impact on reproduction was observed (50.70% inhibition in 100 mu g/kg of E-2). We further demonstrated that the exposure of the earthworm Eisenia fetida to a contaminant of emerging concern, 17 beta-oestradiol (E2), significantly affected the molecules involved in antioxidant defence. Exposure to E2 results in the production of reactive oxygen species (ROS) and the stimulation of antioxidant systems (metallothionein and reduced oxidized glutathione ratio) but not phytochelatins at both the mRNA and translated protein levels. Matrix-assisted laser desorption/ionization (MALDI)-imaging revealed the subcuticular bioaccumulation of oestradiol- 3,4-quinone, altering the levels of local antioxidants in a time-dependent manner. Conclusions/Significance The present study illustrates that although most invertebrates do not possess oestrogen receptors, these organisms can be affected by oestrogen hormones, likely reflecting free diffusion into the cellular microenvironment with subsequent degradation to molecules that undergo redox cycling, producing ROS, thereby increasing environmental contamination that also perilously affects keystone animals, forming lower trophic levels.en
dc.formattextcs
dc.format.extent1-17cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPLOS ONE. 2015, vol. 10, issue 12, p. 1-17.en
dc.identifier.doi10.1371/journal.pone.0145426cs
dc.identifier.issn1932-6203cs
dc.identifier.other123343cs
dc.identifier.urihttp://hdl.handle.net/11012/63710
dc.language.isoencs
dc.publisherPLOScs
dc.relation.ispartofPLOS ONEcs
dc.relation.urihttp://europepmc.org/articles/PMC4690593?pdf=rendercs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1932-6203/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectDISRUPTING COMPOUNDSen
dc.subjectMETALLOTHIONEINen
dc.subjectWATERen
dc.subjectPHARMACEUTICALSen
dc.subjectCONTAMINANTSen
dc.subjectEXPRESSIONen
dc.subjectHORMONESen
dc.subjectSOILSen
dc.subjectOLIGOCHAETAen
dc.subjectPOLLUTANTSen
dc.titleExposure to 17 beta-Oestradiol Induces Oxidative Stress in the Non-Oestrogen Receptor Invertebrate Species Eisenia fetidaen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-123343en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:03:59en
sync.item.modts2020.08.04 12:30:27en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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