Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry

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dc.contributor.authorMiglbauer, Evacs
dc.contributor.authorAbudllaeva, Oliya S.cs
dc.contributor.authorGryszel, Maciejcs
dc.contributor.authorGlowacki, Eric Danielcs
dc.coverage.issue17cs
dc.coverage.volume24cs
dc.date.accessioned2024-02-19T15:46:13Z
dc.date.available2024-02-19T15:46:13Z
dc.date.issued2023-09-01cs
dc.description.abstractReactive oxygen species (ROS) are an integral part of many anticancer therapies. Fenton-like processes involving reactions of peroxides with transition metal ions are a particularly potent and tunable subset of ROS approaches. Precise on-demand dosing of the Fenton reaction is an area of great interest. Herein, we present a concept of an electrochemical faradaic pixel that produces controlled amounts of ROS via a Fenton-like process. The pixel comprises a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide. The anode is made of chromium, which is electrochemically corroded to yield chromium ions. Peroxide and chromium interact to form a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. After benchmarking the electrochemical properties of this type of device, we demonstrate how it can be used under in vitro conditions with a cancer cell line. The faradaic Fenton pixel is a general and scalable concept that can be used for on-demand delivery of redox-active products for controlling a physiological outcome.en
dc.formattextcs
dc.format.extent1-14cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationChembiochem : a European journal of chemical biology. 2023, vol. 24, issue 17, p. 1-14.en
dc.identifier.doi10.1002/cbic.202300353cs
dc.identifier.issn1439-7633cs
dc.identifier.orcid0000-0002-0280-8017cs
dc.identifier.other184657cs
dc.identifier.urihttps://hdl.handle.net/11012/245065
dc.language.isoencs
dc.publisherWiley-VCHcs
dc.relation.ispartofChembiochem : a European journal of chemical biologycs
dc.relation.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1439-7633/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectbioelectronicsen
dc.subjectFenton reactionen
dc.subjectoxygen reduction reactionen
dc.subjectreactive oxygen speciesen
dc.titleFaradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistryen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-184657en
sync.item.dbtypeVAVen
sync.item.insts2024.02.19 16:46:13en
sync.item.modts2024.02.19 16:12:48en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Bioelektronické materiály a systémycs
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