Poly(3-hydroxybutyrate) (PHB) and Polycaprolactone (PCL) Based Blends for Tissue Engineering and Bone Medical Applications Processed by FDM 3D Printing

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dc.contributor.authorKrobot, Štěpáncs
dc.contributor.authorMelčová, Veronikacs
dc.contributor.authorMenčík, Přemyslcs
dc.contributor.authorKontárová, Soňacs
dc.contributor.authorRampichová, Michaelacs
dc.contributor.authorHedvičáková, Věracs
dc.contributor.authorMojžišová, Emacs
dc.contributor.authorBaco, Andrejcs
dc.contributor.authorPřikryl, Radekcs
dc.coverage.issue10cs
dc.coverage.volume15cs
dc.date.issued2023-05-22cs
dc.description.abstractIn the presented work, poly(3-hydroxybutyrate)-PHB-based composite blends for bone medical applications and tissue engineering are prepared and characterized. PHB used for the work was in two cases commercial and, in one case, was extracted by the chloroform-free route. PHB was then blended with poly(lactic acid) (PLA) or polycaprolactone (PCL) and plasticized by oligomeric adipate ester (Syncroflex, SN). Tricalcium phosphate (TCP) particles were used as a bioactive filler. Prepared polymer blends were processed into the form of 3D printing filaments. The samples for all the tests performed were prepared by FDM 3D printing or compression molding. Differential scanning calorimetry was conducted to evaluate the thermal properties, followed by optimization of printing temperature by temperature tower test and determination of warping coefficient. Tensile test, three-point flexural test, and compression test were performed to study the mechanical properties of materials. Optical contact angle measurement was conducted to determine the surface properties of these blends and their influence on cell adhesion. Cytotoxicity measurement of prepared blends was conducted to find out whether the prepared materials were non-cytotoxic. The best temperatures for 3D printing were 195/190, 195/175, and 195/165 degrees C for PHB-soap/PLA-SN, PHB/PCL-SN, and PHB/PCL-SN-TCP, respectively. Their mechanical properties (strengths similar to 40 MPa, moduli similar to 2.5 GPa) were comparable with human trabecular bone. The calculated surface energies of all blends were similar to 40 mN/m. Unfortunately, only two out of three materials were proven to be non-cytotoxic (both PHB/PCL blends).en
dc.formattextcs
dc.format.extent1-17cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationPolymers. 2023, vol. 15, issue 10, p. 1-17.en
dc.identifier.doi10.3390/polym15102404cs
dc.identifier.issn2073-4360cs
dc.identifier.orcid0000-0002-8647-2097cs
dc.identifier.orcid0000-0002-2124-6953cs
dc.identifier.orcid0000-0002-1914-8764cs
dc.identifier.orcid0000-0002-7525-9610cs
dc.identifier.orcid0000-0002-7811-9840cs
dc.identifier.other183556cs
dc.identifier.researcheridHHN-0528-2022cs
dc.identifier.researcheridABD-4360-2020cs
dc.identifier.researcheridABD-2493-2020cs
dc.identifier.researcheridE-8210-2010cs
dc.identifier.scopus57984865200cs
dc.identifier.scopus57204110910cs
dc.identifier.urihttp://hdl.handle.net/11012/209755
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofPolymerscs
dc.relation.urihttps://www.mdpi.com/2073-4360/15/10/2404cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2073-4360/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subject3D printingen
dc.subjectFDMen
dc.subjectpoly(3-hydroxybutyrate)en
dc.subjectbone tissue engineeringen
dc.subjectscaffolden
dc.subjectbiocompatibilityen
dc.subjectpolycaprolactoneen
dc.subjectpolylactic aciden
dc.titlePoly(3-hydroxybutyrate) (PHB) and Polycaprolactone (PCL) Based Blends for Tissue Engineering and Bone Medical Applications Processed by FDM 3D Printingen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-183556en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:00en
sync.item.modts2025.01.17 16:46:49en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav chemie materiálůcs
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Centrum materiálového výzkumucs
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