Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems

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dc.contributor.authorTrudičová, Monikacs
dc.contributor.authorPapežíková, Hanacs
dc.contributor.authorSedláček, Petrcs
dc.contributor.authorPekař, Miloslavcs
dc.date.issued2022-01-01cs
dc.description.abstractThe transport and barrier properties are important material characteristics in terms of the development of the targeted drug delivery systems. Therefore, this work focused on the study of the possibility of influencing these properties and internal architecture in a model hydrogel system formed by a semi-interpenetrating polymer network with an incorporated polyelectrolyte component. Due to its application potential and its extensive use in medicine, poly(2-hydroxyethyl methacrylate) was chosen as the model hydrogel system for this work. Sodium polystyrene sulfonate was used as the interpenetrating linear polymer. Scanning electron microscopy was used to examine the structure of the three-dimensional hydrogel network. Transport properties were monitored by diffusion tests. Furthermore, diffusion through the hydrogel (barrier properties) was monitored using diffusion cells (Franz cells, horizontal cells). The usability of the semi-interpenetrating polymer network concept for the preparation of materials with tunable relevant properties was confirmed on the proposed materials.en
dc.formattextcs
dc.format.extent280-285cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationCONFERENCE PROCEEDINGS - NANOCON 2021. 2022, p. 280-285.en
dc.identifier.doi10.37904/nanocon.2021.4350cs
dc.identifier.isbn978-80-88365-00-6cs
dc.identifier.orcid0000-0001-7268-5641cs
dc.identifier.orcid0000-0002-6211-9643cs
dc.identifier.orcid0000-0002-3878-0917cs
dc.identifier.other179527cs
dc.identifier.scopus57207823371cs
dc.identifier.scopus25621752900cs
dc.identifier.urihttp://hdl.handle.net/11012/208761
dc.language.isoencs
dc.publisherTANGER Ltd.cs
dc.relation.ispartofCONFERENCE PROCEEDINGS - NANOCON 2021cs
dc.relation.urihttps://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systemscs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjecthydrogelen
dc.subjectpoly(2-hydroxyethyl methacrylate)en
dc.subjecttransport propertiesen
dc.subjectdrug delivery systemsen
dc.titleTailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systemsen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-179527en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:38:55en
sync.item.modts2025.01.17 15:28:48en
thesis.grantorVysoké učení technické v Brně. Fakulta chemická. Ústav fyzikální a spotřební chemiecs
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