Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems
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Date
2022-01-01
Authors
Trudičová, Monika
Papežíková, Hana
Sedláček, Petr
Pekař, Miloslav
0000-0001-7268-5641Advisor
Referee
Mark
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Publisher
TANGER Ltd.
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Abstract
The transport and barrier properties are important material characteristics in terms of the development of the targeted drug delivery systems. Therefore, this work focused on the study of the possibility of influencing these properties and internal architecture in a model hydrogel system formed by a semi-interpenetrating polymer network with an incorporated polyelectrolyte component. Due to its application potential and its extensive use in medicine, poly(2-hydroxyethyl methacrylate) was chosen as the model hydrogel system for this work. Sodium polystyrene sulfonate was used as the interpenetrating linear polymer. Scanning electron microscopy was used to examine the structure of the three-dimensional hydrogel network. Transport properties were monitored by diffusion tests. Furthermore, diffusion through the hydrogel (barrier properties) was monitored using diffusion cells (Franz cells, horizontal cells). The usability of the semi-interpenetrating polymer network concept for the preparation of materials with tunable relevant properties was confirmed on the proposed materials.
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Citation
CONFERENCE PROCEEDINGS - NANOCON 2021. 2022, p. 280-285.
https://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systems
https://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systems
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Peer-reviewed
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en