BenchStab: A tool for automated querying of web-based stability predictors

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dc.contributor.authorVelecký, Jancs
dc.contributor.authorBerezný, Matejcs
dc.contributor.authorMusil, Milošcs
dc.contributor.authorDamborský, Jiřícs
dc.contributor.authorBednář, Davidcs
dc.contributor.authorMazurenko, Stanislavcs
dc.coverage.issue9cs
dc.coverage.volume40cs
dc.date.issued2024-09-15cs
dc.description.abstractProtein design requires information about how mutations affect protein stability. Many web-based predictors are available for this purpose, yet comparing them or using them en masse is difficult. Here, we present BenchStab, a console tool/Python package for easy and quick execution of 19 predictors and result collection on a list of mutants. Moreover, the tool is easily extensible with additional predictors. We created an independent dataset derived from the FireProtDB and evaluated 24 different prediction methods.en
dc.description.abstractProtein design requires information about how mutations affect protein stability. Many web-based predictors are available for this purpose, yet comparing them or using them en masse is difficult. Here, we present BenchStab, a console tool/Python package for easy and quick execution of 19 predictors and result collection on a list of mutants. Moreover, the tool is easily extensible with additional predictors. We created an independent dataset derived from the FireProtDB and evaluated 24 different prediction methods.en
dc.formattextcs
dc.format.extent1-8cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationBIOINFORMATICS. 2024, vol. 40, issue 9, p. 1-8.en
dc.identifier.doi10.1093/bioinformatics/btae553cs
dc.identifier.issn1367-4803cs
dc.identifier.orcid0000-0001-9373-7930cs
dc.identifier.other189729cs
dc.identifier.urihttp://hdl.handle.net/11012/252347
dc.language.isoencs
dc.publisherOxford University Presscs
dc.relation.ispartofBIOINFORMATICScs
dc.relation.urihttps://academic.oup.com/bioinformatics/article/40/9/btae553/7755040cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1367-4803/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectprediction of stabilityen
dc.subjectprotein stabilityen
dc.subjectweb-toolsen
dc.subjectbenchmarkingen
dc.subjectprediction of stability
dc.subjectprotein stability
dc.subjectweb-tools
dc.subjectbenchmarking
dc.titleBenchStab: A tool for automated querying of web-based stability predictorsen
dc.title.alternativeBenchStab: A tool for automated querying of web-based stability predictorsen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189729en
sync.item.dbtypeVAVen
sync.item.insts2025.10.14 14:13:15en
sync.item.modts2025.10.14 10:07:52en
thesis.grantorVysoké učení technické v Brně. Fakulta informačních technologií. Ústav informačních systémůcs

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