Lead Ions Encapsulated in Liposomes and Their Effect on Staphylococcus aureus

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dc.contributor.authorKenšová, Renátacs
dc.contributor.authorBlažková, Ivacs
dc.contributor.authorKonečná, Mariecs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorchudobova, Dagmarcs
dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorVaculovičová, Markétacs
dc.contributor.authorHynek, Davidcs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorBeklová, Miroslavacs
dc.contributor.authorKizek, Renécs
dc.coverage.issue12cs
dc.coverage.volume10cs
dc.date.accessioned2020-08-04T11:03:48Z
dc.date.available2020-08-04T11:03:48Z
dc.date.issued2013-12-01cs
dc.description.abstractThe aim of the study was the preparation of a liposome complex with encapsulated lead ions, which were electrochemically detected. In particular, experiments were focused on the potential of using an electrochemical method for the determination of free and liposome-encapsulated lead and determination of the encapsulation efficiency preventing the lead toxicity. Primarily, encapsulation of lead ions in liposomes and confirmation of successful encapsulation by electrochemical methods was done. Further, the reduction effect of the liposome matrix on the detected electrochemical signal was monitored. Besides encapsulation itself, comparison of toxicity of free lead ions and lead ions encapsulated in liposome was tested. The calculated IC50 values for evaluating the lead cytotoxicity showed significant differences between the lead enclosed in liposomes (28 mu M) and free lead ions (237 mu M). From the cytotoxicity studies on the bacterial strain of S. aureus it was observed that the free lead ions are less toxic in comparison with lead encapsulated in liposomes. Liposomes appear to be a suitable carrier of various substances through the inner cavity. Due to the liposome structure the lead enclosed in the liposome is more easily accepted into the cell structure and the toxicity of the enclosed lead is higher in comparison to free lead ions.en
dc.formattextcs
dc.format.extent6687-6700cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationInternational Journal of Environmental Research and Public Health. 2013, vol. 10, issue 12, p. 6687-6700.en
dc.identifier.doi10.3390/ijerph10126687cs
dc.identifier.issn1660-4601cs
dc.identifier.other145217cs
dc.identifier.urihttp://hdl.handle.net/11012/181134
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofInternational Journal of Environmental Research and Public Healthcs
dc.relation.urihttps://www.mdpi.com/1660-4601/10/12/6687cs
dc.rightsCreative Commons Attribution 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1660-4601/cs
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/cs
dc.subjectleaden
dc.subjectliposomeen
dc.subjecttoxicityen
dc.subjectdifferential pulse voltammetryen
dc.subjectcyclic voltammetryen
dc.subjectatomic absorption spectrometryen
dc.subjectIC50en
dc.subjectStaphylococcus aureusen
dc.titleLead Ions Encapsulated in Liposomes and Their Effect on Staphylococcus aureusen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-145217en
sync.item.dbtypeVAVen
sync.item.insts2020.08.04 13:03:48en
sync.item.modts2020.08.04 12:46:34en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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