Novel Ruthenium coordinate compound combined with Schiff base and benzimidazole as a potent antibacterial agent against VRSA and MRSA

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dc.contributor.authorSur, Vishma Pratapcs
dc.contributor.authorMazumdar, Anindacs
dc.contributor.authorKopel, Pavelcs
dc.contributor.authorMoulick, Amitavacs
dc.date.accessioned2020-01-24T11:53:34Z
dc.date.available2020-01-24T11:53:34Z
dc.date.issued2019-12-31cs
dc.description.abstractThe rise of antibiotic-resistant strains is an important public health problem and thus the development of an alternative to antibiotics is imminent. The Ruthenium–Schiff base with benzimidazole (RU–S2), a co-ordinate compound is novel and first of its kind to be synthesized in such combination. The aim of the experiment is based on the synthesis of RU–S2 and to study its antibacterial activity against the pathogenic resistant strains of Staphylococcus aureus like Vancomycin-resistant Staphylococcus aureus (VRSA) and Methicillin-resistant Staphylococcus aureus (MRSA). The antibacterial activity was studied using growth curve analysis based on turbidimetry which was confirmed by the fluorescence live/dead cell microscopic imaging of the bacteria after treatment with RU–S2. Lastly, the cytotoxicity test was performed by 3-(4,5-Dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) assay against human normal and cancer epithelial cell lines to understand the toxic effects of RU-S2 at 160 µg/ml concentration. The concentration 160 µg/ml of RU–S2 was very effective against those resistant strains and also nontoxic in this concentration. Thus RU-S2 can be used as an efficient alternative to antibiotics that have promising antibacterial efficacy against the pathogenic strains with no toxicity and biocompatibility towards human cells.en
dc.formattextcs
dc.format.extent654-658cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationMendelNet 2019 Proceedings of 26th International PhD Students Conference. 2019, p. 654-658.en
dc.identifier.isbn978-80-7509-688-3cs
dc.identifier.orcidE-5711-2012cs
dc.identifier.orcidI-9677-2016cs
dc.identifier.other161421cs
dc.identifier.researcherid0000-0002-1175-7194cs
dc.identifier.researcherid0000-0002-4985-7115cs
dc.identifier.researcherid0000-0003-4216-9544cs
dc.identifier.researcherid0000-0001-5769-6748cs
dc.identifier.scopus6603604023cs
dc.identifier.scopus55783172600cs
dc.identifier.urihttp://hdl.handle.net/11012/184136
dc.language.isoencs
dc.publisherMendel University in Brnocs
dc.relation.ispartofMendelNet 2019 Proceedings of 26th International PhD Students Conferencecs
dc.relation.urihttps://mendelnet.cz/artkey/mnt-201901-0126_Novel-Ruthenium-coordinate-compound-combined-with-Schiff-base-and-benzimidazole-as-a-potent-antibacterial-agent.php?back=/magno/mnt/2019/mn1.php?secid=4cs
dc.rights(C) Mendel University in Brnocs
dc.rights.accessopenAccesscs
dc.subjectantibiotic-resistanten
dc.subjectcoordinate compounden
dc.subjectantibacterial activityen
dc.subjectVRSAen
dc.subjectMRSAen
dc.titleNovel Ruthenium coordinate compound combined with Schiff base and benzimidazole as a potent antibacterial agent against VRSA and MRSAen
dc.type.driverconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-161421en
sync.item.dbtypeVAVen
sync.item.insts2023.07.24 13:00:18en
sync.item.modts2023.07.24 12:14:55en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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