An Investigation of Glutathione-Platinum(II) Interactions by Means of the Flow Injection Analysis Using Glassy Carbon Electrode

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dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorKřížková, Soňacs
dc.contributor.authorAdam, Vojtěchcs
dc.contributor.authorTrnková, Libušecs
dc.contributor.authorHubálek, Jaromírcs
dc.contributor.authorKizek, Renécs
dc.coverage.issue1cs
dc.coverage.volume7cs
dc.date.issued2007-07-20cs
dc.description.abstractGlutathione was discovered by M. J. de Rey Pailhade at the end of the 19th century as the substance (hydrogénant le soufre), which was renamed by F.G. Hopkins in 1921. Hopkins first characterised the compound as a dipeptide of glutamic acid and cysteine. Few years later he suggested the correct structure to be a tripeptide which also contains glycine. GSH as a ubiquitous tripeptide thiol is a vital intra- and extra-cellular protective antioxidant. It plays a number of key roles in the controlling of signalling processes, detoxifying of some xenobiotics and heavy metals etc. Glutathione is found almost exclusively in its reduced form; since the enzyme, which reverts it from its oxidized form (GSSG) called glutathione reductase, is constitutively active and inducible upon oxidative stress. In fact, the ratio of reduced to oxidized glutathione within cells is often used as a marker of cytotoxicity.en
dc.formattextcs
dc.format.extent1256-1270cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationSENSORS. 2007, vol. 7, issue 1, p. 1256-1270.en
dc.identifier.doi10.3390/s7071256cs
dc.identifier.issn1424-8220cs
dc.identifier.orcid0000-0001-7607-5058cs
dc.identifier.orcid0000-0002-0479-8369cs
dc.identifier.orcid0000-0002-8527-286Xcs
dc.identifier.orcid0000-0002-7496-2558cs
dc.identifier.other44510cs
dc.identifier.researcheridE11072012cs
dc.identifier.researcheridE-9617-2012cs
dc.identifier.researcheridD-7686-2012cs
dc.identifier.researcheridD-7753-2012cs
dc.identifier.scopus14012648400cs
dc.identifier.scopus57207501711cs
dc.identifier.urihttp://hdl.handle.net/11012/70085
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofSENSORScs
dc.relation.urihttp://www.mdpi.com/1424-8220/7/7/1256cs
dc.rightsCreative Commons Attribution 3.0 Unportedcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/1424-8220/cs
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/cs
dc.subjectGlutathioneen
dc.subjectCarbon paste electrodeen
dc.subjectThiolsen
dc.subjectCisplatinen
dc.subjectCanceren
dc.subjectFlow injection analysis with electrochemical detection.en
dc.titleAn Investigation of Glutathione-Platinum(II) Interactions by Means of the Flow Injection Analysis Using Glassy Carbon Electrodeen
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-44510en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:41:25en
sync.item.modts2025.01.17 18:36:43en
thesis.grantorVysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií. Ústav mikroelektronikycs
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