3D atlas of the human fetal chondrocranium in the middle trimester

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dc.contributor.authorKaiser, Markétacs
dc.contributor.authorZikmund, Tomášcs
dc.contributor.authorSiddharth, Voracs
dc.contributor.authorMetscher, Briancs
dc.contributor.authorAdameyko, Igorcs
dc.contributor.authorRichman, Joy M.cs
dc.contributor.authorKaiser, Jozefcs
dc.coverage.issue1cs
dc.coverage.volume11cs
dc.date.issued2024-06-13cs
dc.description.abstractThe chondrocranium provides the key initial support for the fetal brain, jaws and cranial sensory organs in all vertebrates. The patterns of shaping and growth of the chondrocranium set up species-specific development of the entire craniofacial complex. The 3D development of chondrocranium have been studied primarily in animal model organisms, such as mice or zebrafish. In comparison, very little is known about the full 3D human chondrocranium, except from drawings made by anatomists many decades ago. The knowledge of human-specific aspects of chondrocranial development are essential for understanding congenital craniofacial defects and human evolution. Here advanced microCT scanning was used that includes contrast enhancement to generate the first 3D atlas of the human fetal chondrocranium during the middle trimester (13 to 19 weeks). In addition, since cartilage and bone are both visible with the techniques used, the endochondral ossification of cranial base was mapped since this region is so critical for brain and jaw growth. The human 3D models are published as a scientific resource for human development.en
dc.formattextcs
dc.format.extent1-6cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationScientific data. 2024, vol. 11, issue 1, p. 1-6.en
dc.identifier.doi10.1038/s41597-024-03455-1cs
dc.identifier.issn2052-4463cs
dc.identifier.orcid0000-0002-5200-7365cs
dc.identifier.orcid0000-0003-2948-5198cs
dc.identifier.orcid0000-0002-7397-125Xcs
dc.identifier.other189053cs
dc.identifier.researcheridV-3696-2018cs
dc.identifier.researcheridG-9491-2014cs
dc.identifier.researcheridD-6800-2012cs
dc.identifier.scopus7402184758cs
dc.identifier.urihttp://hdl.handle.net/11012/249335
dc.language.isoencs
dc.publisherNATURE PORTFOLIOcs
dc.relation.ispartofScientific datacs
dc.relation.urihttps://www.nature.com/articles/s41597-024-03455-1cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2052-4463/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectchondrocraniumen
dc.subjecthuman embryosen
dc.subjectcartilage developmenten
dc.subjectmicroCTen
dc.subjecttomographyen
dc.title3D atlas of the human fetal chondrocranium in the middle trimesteren
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-189053en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:51:10en
sync.item.modts2025.01.17 16:39:17en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Pokročilé instrumentace a metody pro charakterizace materiálůcs
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Pokročilé instrumentace a metody pro charakterizace materiálů