Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

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dc.contributor.authorBodláková, Karolínacs
dc.contributor.authorČerný, Jancs
dc.contributor.authorŠtěrbová, Helenacs
dc.contributor.authorGuráň, Romancs
dc.contributor.authorZítka, Ondřejcs
dc.contributor.authorKodrík, Daliborcs
dc.coverage.issue1cs
dc.coverage.volume14cs
dc.date.issued2022-01-31cs
dc.description.abstractBees originally developed their stinging apparatus and venom against members of their own species from other hives or against predatory insects. Nevertheless, the biological and biochemical response of arthropods to bee venom is not well studied. Thus, in this study, the physiological responses of a model insect species (American cockroach, Periplaneta americana) to honeybee venom were investigated. Bee venom toxins elicited severe stress (LD50 = 1.063 uL venom) resulting in a significant increase in adipokinetic hormones (AKHs) in the cockroach central nervous system and haemolymph. Venom treatment induced a large destruction of muscle cell ultrastructure, especially myofibrils and sarcomeres. Interestingly, co-application of venom with cockroach Peram-CAH-II AKH eliminated this effect. Envenomation modulated the levels of carbohydrates, lipids, and proteins in the haemolymph and the activity of digestive amylases, lipases, and proteases in the midgut. Bee venom significantly reduced vitellogenin levels in females. Dopamine and glutathione (GSH and GSSG) insignificantly increased after venom treatment. However, dopamine levels significantly increased after Peram-CAH-II application and after co-application with bee venom, while GSH and GSSG levels immediately increased after co-application. The results suggest a general reaction of the cockroach body to bee venom and at least a partial involvement of AKHs.en
dc.formattextcs
dc.format.extent1-18cs
dc.format.mimetypeapplication/pdfcs
dc.identifier.citationToxins. 2022, vol. 14, issue 1, p. 1-18.en
dc.identifier.doi10.3390/toxins14010011cs
dc.identifier.issn2072-6651cs
dc.identifier.orcid0000-0002-2912-714Xcs
dc.identifier.orcid0000-0001-7607-5058cs
dc.identifier.other178332cs
dc.identifier.researcheridC-2610-2016cs
dc.identifier.researcheridE11072012cs
dc.identifier.scopus14012648400cs
dc.identifier.urihttp://hdl.handle.net/11012/208106
dc.language.isoencs
dc.publisherMDPIcs
dc.relation.ispartofToxinscs
dc.relation.urihttps://www.mdpi.com/2072-6651/14/1/11cs
dc.rightsCreative Commons Attribution 4.0 Internationalcs
dc.rights.accessopenAccesscs
dc.rights.sherpahttp://www.sherpa.ac.uk/romeo/issn/2072-6651/cs
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/cs
dc.subjectadipokinetic hormoneen
dc.subjectAmerican cockroachen
dc.subjectdopamineen
dc.subjecthoney beeen
dc.subjectmelittinen
dc.subjectmetabolismen
dc.subjectmuscle ultrastructureen
dc.subjectvitellogeninen
dc.titleInsect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?en
dc.type.driverarticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen
sync.item.dbidVAV-178332en
sync.item.dbtypeVAVen
sync.item.insts2025.02.03 15:50:13en
sync.item.modts2025.01.17 18:41:59en
thesis.grantorVysoké učení technické v Brně. Středoevropský technologický institut VUT. Chytré nanonástrojecs
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